GLK Antibody (YA10070)
(Synonyms: APG4D; AUTL4; Cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D)GLK Antibody (YA10070) is a Mouse-derived and non-conjugated IgM Monoclonal antibody, targeting to GLK.
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Host:
Mouse
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Isotype:
IgM
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
GLK Antibody (YA10070) is a Mouse-derived and non-conjugated IgM Monoclonal antibody, targeting to GLK.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 101 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 101 kDa
Purified recombinant protein of human GLK.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgM
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GLK is a Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway[1][2].
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Expression
Tissue_Specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. -
Isoforms & Post-Translational Modification
GLK has 3 isoforms, Q8IVH8-1: amino acid length is 894, molecular weight is 101316 Da (predicted); Q8IVH8-2: amino acid length is 884, molecular weight is 100133 Da (predicted); Q8IVH8-3: amino acid length is 873, molecular weight is 98954 Da (predicted).
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Subunit
Interacts with SH3GL2.
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SwissProt ID
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Synonyms
APG4D; AUTL4; Cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D
Documentation
References
[1]. Diener K, et al. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9687-92. [Content Brief]
[2]. Meng Z, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015 Oct 5;6:8357. [Content Brief]
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