PAR6 Antibody (YA1536)
(Synonyms: PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha)PAR6 Antibody (YA1536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50 |
Product Details
PAR6 Antibody (YA1536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 37 kDa
Entrez Gene: 50855 Human ; 56513 Mouse ;
SwissProt: Q9NPB6 Human ; Q9Z101 Mouse ; Q6B4M5 Rat
OMIM: 607484 Human
A synthesized peptide derived from human PAR6 aa1-66/346.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PAR6 is an Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization[1][2].
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Subcellular Localization
Cytoplasm; Cell membrane; Cell projection, ruffle; Cell junction, tight junction; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Expression
Tissue_specificity:Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta -
Isoforms & Post-Translational Modification
Q9NPB6 has 2 isomers: Q9NPB6-1: 37388 Da (predicted); Q9NPB6-2: 37317 Da (predicted).
Phosphorylated by the TGF-beta receptor;Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation -
Subunit
Interacts with MAP2K5 (By similarity). Interacts with DCTN1 and PCM1 (PubMed:20719959)
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SwissProt ID
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Synonyms
PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha
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Research Field
Cell Biology
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