2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. PAR6 Antibody (YA1536)

PAR6 Antibody (YA1536)

Art. -Nr.: HY-P81791
User Guide for Antibodies Technical Support

PAR6 Antibody (YA1536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.

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20 μL Angebot einholen 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
50 μL Angebot einholen 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
100 μL Angebot einholen 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
250 μL   Angebot einholen  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

  • Verweise

Beschreibung

PAR6 Antibody (YA1536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molekulargewicht
Predicted band size: 37 kDa;
Observed band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human PAR6 aa1-66/346.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Reinheit Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959)
Subcellular Localization：Cytoplasm; Cell membrane; Cell projection, ruffle; Cell junction, tight junction; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Expression：
Tissue_specificity:Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta
Isoforms & Post-Translational Modification：Q9NPB6 has 2 isomers: Q9NPB6-1: 37388 Da (predicted); Q9NPB6-2: 37317 Da (predicted).
Phosphorylated by the TGF-beta receptor;Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation
Subunit：Interacts with MAP2K5 (By similarity). Interacts with DCTN1 and PCM1 (PubMed:20719959)
Database

Entrez Gene: 50855 Human ; 56513 Mouse ;

SwissProt: Q9NPB6 Human ; Q9Z101 Mouse ; Q6B4M5 Rat

OMIM: 607484 Human

Research Field

Cell Biology
Synonyms
PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha
Dokumentation
User Guide for Antibodies (1077 KB)
Verweise

PAR6 Antibody (YA1536) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PAR6 Antibody (YA1536)
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