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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies
  5. Phospho-Dishevelled 2 (Ser143) Antibody (YA2688)

Phospho-Dishevelled 2 (Ser143) Antibody (YA2688)

Art. -Nr.: HY-P82943
COA
SDS
User Guide for Antibodies Technical Support

Phospho-Dishevelled 2 (Ser143) Antibody (YA2688) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Dishevelled 2 (Ser143).

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

  • Verweise

Beschreibung

Phospho-Dishevelled 2 (Ser143) Antibody (YA2688) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Dishevelled 2 (Ser143).
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molekulargewicht
Predicted band size: 79 kDa;
Observed band size: 90-95 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser143 of human Dishevelled 2
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Reinheit Affinity Purified
Conjugation Non-conjugated Modification Phosphorylated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling
Subcellular Localization：Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytosol; Cytoplasmic vesicle; Nucleus
Subunit：Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and FAM105B/otulin. Interacts with DCDC2. Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (PubMed:25805136). Interacts with MAPK15 (By similarity). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with LMBR1L (By similarity). Interacts with IRS1 and IRS2; these interactions decrease 'Lys-63'-linked ubiquitination of DVL2 and stabilize DVL2 protein via suppressing its autophagy-mediated degradation (PubMed:24616100)
Database

Entrez Gene: 1856 Human ; 13543 Mouse ; 303251 Rat

SwissProt: O14641 Human ; Q60838 Mouse ;

OMIM: 602151 Human

Research Field

Stem Cells
Synonyms
DSH homolog 2
Dokumentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
Verweise

Phospho-Dishevelled 2 (Ser143) Antibody (YA2688) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-Dishevelled 2 (Ser143) Antibody (YA2688)
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