Activated Protein C (390-404), human
Based on 4 publication(s) in Google Scholar
Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of APC. Activated Protein C (390-404), human inhibits APC-catalyzed inactivation of factor Va.
For research use only. We do not sell to patients.
- Purity: 98.74%
- CAS No.: 146340-20-7
- Formula: C91H130N22O23
- Molecular Weight:1900.14
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Activated Protein C (390-404), human
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Biological Activity
Activated Protein C (390-404), human potently inhibits the anticoagulant activity of APC in normal human plasma, protein S-deficient plasma, and coagulation factor VIII-deficient plasma in APTT and single-stage Xa coagulation assays, with an IC50 of 5 μM[1].
Activated Protein C (390-404), human potently inhibits APC-catalyzed inactivation of purified coagulation factor Va in the presence or absence of phospholipid vesicles; it exhibits an IC50 of 4 μM in the presence of phospholipids[1].
Activated Protein C (390-404), human (4.4 μM; 30 min) competes with native PC for binding to immunoaffinity-purified anti-(390-404) antibody, with a half-maximal competition concentration of 4.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 146340-20-7
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Appearance Solid
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Molecular Weight 1900.14
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Formula C91H130N22O23
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Color White to off-white
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Sequence
Tyr-Gly-Val-Tyr-Thr-Lys-Val-Ser-Arg-Tyr-Leu-Asp-Trp-Ile-His
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Sequence Shortening
YGVYTKVSRYLDWIH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Biosci
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis. [Abstract]2022 Jul 22;12(1):114. PMID: 35869501 -
Thromb Res
2022 Nov:219:1-13. PMID: 36084517 -
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Solvent & Solubility
H2O : 0.5 mg/mL (0.26 mM; Need ultrasonic)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Activated Protein C (390-404), human Related Classifications
HY-P1918 Related Classifications
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