CTNNA1 - catenin alpha 1 Gene
Also Known as MDPT2; CAP102
Species: Homo sapiens
About CTNNA1
This gene has 44 transcripts (splice variants), 226 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in esophagus (RPKM 69.8), lung (RPKM 58.9) and 25 other tissues.
Summary
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting Cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
CTNNA1 Products (37)
| mRNA | Protein | Name |
|---|---|---|
| NM_001290307.3 | NP_001277236.1 | catenin alpha-1 isoform 2 |
| NM_001290309.3 | NP_001277238.1 | catenin alpha-1 isoform 3 |
| NM_001290310.3 | NP_001277239.1 | catenin alpha-1 isoform 4 precursor |
| NM_001290312.1 | NP_001277241.1 | catenin alpha-1 isoform 5 |
| NM_001323982.2 | NP_001310911.1 | catenin alpha-1 isoform 1 |
| NM_001323983.1 | NP_001310912.1 | catenin alpha-1 isoform 1 |
| NM_001323984.2 | NP_001310913.1 | catenin alpha-1 isoform 1 |
| NM_001323985.2 | NP_001310914.1 | catenin alpha-1 isoform 6 |
| NM_001323986.2 | NP_001310915.1 | catenin alpha-1 isoform 7 |
| NM_001323987.1 | NP_001310916.1 | catenin alpha-1 isoform 5 |
| NM_001323988.1 | NP_001310917.1 | catenin alpha-1 isoform 5 |
| NM_001323989.1 | NP_001310918.1 | catenin alpha-1 isoform 5 |
| NM_001323990.1 | NP_001310919.1 | catenin alpha-1 isoform 5 |
| NM_001323991.1 | NP_001310920.1 | catenin alpha-1 isoform 5 |
| NM_001323992.1 | NP_001310921.1 | catenin alpha-1 isoform 5 |
| NM_001323993.1 | NP_001310922.1 | catenin alpha-1 isoform 5 |
| NM_001323994.1 | NP_001310923.1 | catenin alpha-1 isoform 5 |
| NM_001323995.1 | NP_001310924.1 | catenin alpha-1 isoform 5 |
| NM_001323996.1 | NP_001310925.1 | catenin alpha-1 isoform 5 |
| NM_001323997.1 | NP_001310926.1 | catenin alpha-1 isoform 5 |
| NM_001323998.1 | NP_001310927.1 | catenin alpha-1 isoform 5 |
| NM_001323999.1 | NP_001310928.1 | catenin alpha-1 isoform 5 |
| NM_001324000.1 | NP_001310929.1 | catenin alpha-1 isoform 5 |
| NM_001324001.1 | NP_001310930.1 | catenin alpha-1 isoform 8 |
| NM_001324002.1 | NP_001310931.1 | catenin alpha-1 isoform 9 |
| NM_001324003.1 | NP_001310932.1 | catenin alpha-1 isoform 9 |
| NM_001324004.1 | NP_001310933.1 | catenin alpha-1 isoform 9 |
| NM_001324005.1 | NP_001310934.1 | catenin alpha-1 isoform 9 |
| NM_001324006.1 | NP_001310935.1 | catenin alpha-1 isoform 10 |
| NM_001324007.1 | NP_001310936.1 | catenin alpha-1 isoform 10 |
| NM_001324008.1 | NP_001310937.1 | catenin alpha-1 isoform 10 |
| NM_001324009.1 | NP_001310938.1 | catenin alpha-1 isoform 10 |
| NM_001324010.1 | NP_001310939.1 | catenin alpha-1 isoform 10 |
| NM_001324011.1 | NP_001310940.1 | catenin alpha-1 isoform 11 |
| NM_001324012.1 | NP_001310941.1 | catenin alpha-1 isoform 12 |
| NM_001324013.1 | NP_001310942.1 | catenin alpha-1 isoform 12 |
| NM_001903.5 | NP_001894.2 | catenin alpha-1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables beta-catenin binding |
IPI
IPI: Inferred from physical interaction
|
7650039 | GOA |
| enables cadherin binding |
IPI
IPI: Inferred from physical interaction
|
7650039 | GOA |
| enables gamma-catenin binding |
IPI
IPI: Inferred from physical interaction
|
7650039 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
23292143 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12477722 | GOA |
| enables vinculin binding |
IPI
IPI: Inferred from physical interaction
|
9700171 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cellular response to indole-3-methanol |
IDA
IDA: Inferred from direct assay
|
10868478 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of catenin complex |
IDA
IDA: Inferred from direct assay
|
7650039 | GOA |
| located in cell-cell junction |
IDA
IDA: Inferred from direct assay
|
7650039 | GOA |
CTNNA1 Protein Structure
Vinculin: Vinculin family (19 - 334)
Vinculin: Vinculin family (338 - 867)
- 0
- 200
- 400
- 600
- 800
- 906 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
catenin alpha-1 |
|
CTNNA1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CTNNA1 | P35221 | ECT2 | Homo sapiens | Q9H8V3 | 22750944 | |
|
Intra
|
CTNNA1 | P35221 | VCL | Homo sapiens | P18206-2 | 23292143 | |
|
Intra
|
CTNNA1 | P35221 | VCL | Homo sapiens | P18206-2 | 23292143 | |
|
Cross
|
CTNNA1 | P35221 | Lima1 | Mus musculus | Q9ERG0-2 | 18093941 | |
|
Intra
|
CTNNA1 | P35221 | NFKBIA | Homo sapiens | P25963 | 24509793 | |
|
Intra
|
CTNNA1 | P35221 | NFKBIA | Homo sapiens | P25963 | 24509793 | |
|
Intra
|
CTNNA1 | P35221 | CTNNB1 | Homo sapiens | P35222 | 17052462 | |
|
Intra
|
CTNNA1 | P35221 | CTNNB1 | Homo sapiens | P35222 | 24509793 | |
|
Intra
|
CTNNA1 | P35221 | CTNNB1 | Homo sapiens | P35222 | 12640114 | |
|
Intra
|
CTNNA1 | P35221 | CTNNA1 | Homo sapiens | P35221 | 23292143 | |
|
Intra
|
CTNNA1 | P35221 | APC | Homo sapiens | P25054 | 25241761 | |
|
Intra
|
CTNNA1 | P35221 | EGFR | Homo sapiens | P00533 | 25241761 | |
|
Intra
|
CTNNA1 | P35221 | CDH1 | Homo sapiens | P12830 | 22750944 | |
|
Intra
|
CTNNA1 | P35221 | RACGAP1 | Homo sapiens | Q9H0H5 | 22750944 |
CTNNA1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82312 | CTNNA1 Antibody (YA2057) | WB, IP | Human, Mouse, Rat |
| HY-P82312A | CTNNA1 Antibody (YA2057)(PBS only) | WB, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Macular Dystrophy, Patterned, 2 |
|
|
| Butterfly-Shaped Pigment Dystrophy |
|
|
| Hereditary Breast Ovarian Cancer Syndrome |
|
|
| Colorectal Cancer |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Diffuse Gastric Cancer |
|
|
| Polyposis Syndrome, Hereditary Mixed, 1 |
|
|
| Craniosynostosis |
|
|
| Desmoid Tumor |
|
|
| Macular Dystrophy, Patterned, 1 |
|
|
| Patterned Macular Dystrophy |
|
|
| Blepharocheilodontic Syndrome 1 |
|
|
| Gastric Cancer |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Bladder Cancer |
|
|
| Arrhythmogenic Right Ventricular Cardiomyopathy |
|
|
| Fundus Dystrophy |
|
|
| Endometrial Cancer |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Microinvasive Gastric Cancer |
|
|
| Linitis Plastica |
|
|
| Esophageal Cancer |
|
|
| Tubular Adenocarcinoma |
|
|
| Cholangiocarcinoma |
|
|
| Testicular Cancer |
|
|
| Ovarian Cancer |
|
|
| Dilated Cardiomyopathy |
|
|
| Pancreatic Cancer |
|
|
| Lobular Neoplasia |
|
|
| Juvenile Polyposis Syndrome |
|
|
| Prostate Cancer |
|
|
| Band Heterotopia |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Inflammatory Bowel Disease |
|
|
| Breast Cancer |
|
|
| Exudative Vitreoretinopathy |
|
|
| Myelodysplastic Syndrome |
|
|
| Lynch Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CTNNA1 | MGD | MGI:88274 |
| Rattus norvegicus | CTNNA1 | RGD | RGD:1359485 |
| Felis catus | CTNNA1 | VGNC | VGNC:61254 |
| Macaca mulatta | CTNNA1 | VGNC | VGNC:84291 |
| Bos taurus | CTNNA1 | VGNC | VGNC:27799 |
| Canis familiaris | CTNNA1 | VGNC | VGNC:51706 |
| Others | CTNNA1 | NCBI |