CTNNA1 Antibody (YA2057)

製品番号: HY-P82312: データシート User Guide for Antibodies
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CTNNA1 Antibody (YA2057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTNNA1.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

CTNNA1 Antibody (YA2057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTNNA1.

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 100 kDa;

Observed band size: 100 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P35221

Gene ID

1495 [NCBI]

Immunogen

A synthetic peptide of human alpha 1 Catenin

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation

Subcellular Localization：Cytoplasm, cytoskeleton; Cell junction, adherens junction; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell junction; Cytoplasm; Nucleus; Cell membrane; Peripheral membrane protein; Cytoplasmic side

Expression：
Tissue_specificity:Ubiquitously expressed in normal tissues; Abundantly expressed in brain and cerebellum, also expressed in the placenta, liver, lung, colon, heart, pancreas, stomach and thymus

Isoforms & Post-Translational Modification：P35221 has 3 isomers: P35221-1: 100071 Da (predicted); P35221-2: 102635 Da (predicted); P35221-3: 59550 Da (predicted).
Sumoylated;Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion

Subunit：Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin (By similarity).

Database

Entrez Gene: 1495 Human ; 12385 Mouse ; 307505 Rat

SwissProt: P35221 Human ; P26231 Mouse ;

OMIM: 608970 Human

Research Field

Cell Biology

Synonyms

Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13

ドキュメンテーション

User Guide for Antibodies (1077 KB)