CTNNA1 Antibody (YA2057)
(Synonyms: Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13)CTNNA1 Antibody (YA2057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTNNA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
CTNNA1 Antibody (YA2057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTNNA1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 100 kDa
Entrez Gene: 1495 Human ; 12385 Mouse ; 307505 Rat
SwissProt: P35221 Human ; P26231 Mouse ;
OMIM: 608970 Human
A synthetic peptide of human alpha 1 Catenin
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CTNNA1 associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. May play a crucial role in cell differentiation
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Subcellular Localization
Cytoplasm, cytoskeleton; Cell junction, adherens junction; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell junction; Cytoplasm; Nucleus; Cell membrane; Peripheral membrane protein; Cytoplasmic side
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Expression
Tissue_specificity:Ubiquitously expressed in normal tissues; Abundantly expressed in brain and cerebellum, also expressed in the placenta, liver, lung, colon, heart, pancreas, stomach and thymus -
Isoforms & Post-Translational Modification
P35221 has 3 isomers: P35221-1: 100071 Da (predicted); P35221-2: 102635 Da (predicted); P35221-3: 59550 Da (predicted).
Sumoylated;Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion -
Subunit
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin (By similarity).
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SwissProt ID
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Synonyms
Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
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Research Field
Cell Biology
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