ECT2 - epithelial cell transforming 2 Gene

Also Known as ARHGEF31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1894

About ECT2

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,750,726-172,829,265 (from NCBI)

This gene has 16 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 6.4), colon (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing Mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

ECT2 Products (14)

mRNA	Protein	Name
NM_001258315.2	NP_001245244.1	protein ECT2 isoform a
NM_001258316.2	NP_001245245.1	protein ECT2 isoform b
NM_001349094.2	NP_001336023.1	protein ECT2 isoform c
NM_001349095.2	NP_001336024.1	protein ECT2 isoform c
NM_001349096.2	NP_001336025.1	protein ECT2 isoform c
NM_001349097.2	NP_001336026.1	protein ECT2 isoform d
NM_001349098.2	NP_001336027.1	protein ECT2 isoform a
NM_001349099.2	NP_001336028.1	protein ECT2 isoform a
NM_001349100.2	NP_001336029.1	protein ECT2 isoform a
NM_001349101.2	NP_001336030.1	protein ECT2 isoform e
NM_001349102.2	NP_001336031.1	protein ECT2 isoform f
NM_001349103.2	NP_001336032.1	protein ECT2 isoform g
NM_001349104.2	NP_001336033.1	protein ECT2 isoform g
NM_018098.6	NP_060568.3	protein ECT2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	15642749	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	15254234	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15254234	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15545273	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	19617897	GOA
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19617897	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	15254234	GOA
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	15254234	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	15254234	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21373644	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17115030	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	21373644	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21373644	GOA
involved in positive regulation of cytokinesis	IDA IDA: Inferred from direct assay	15545273	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	12761501	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	15545273	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15254234	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	15254234	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15254234	GOA
part of centralspindlin complex	IDA IDA: Inferred from direct assay	16236794	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	16103226	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16394104	GOA
located in midbody	IDA IDA: Inferred from direct assay	15545273	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15254234	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15254234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECT2 Protein Structure

PTCB-BRCT

BRCT

RhoGEF

0
200
400
600
800
914 a.a.

Protein Preferred Names	Protein Names
protein ECT2	epithelial cell-transforming sequence 2 oncogene

ECT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	19468300
Intra	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	ECT2	Q9H8V3	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	19468302
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Y2H	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	ITC	25068414
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	CDH1	Homo sapiens	P12830	Anti Bait CoIP	22750944

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104023	ZK-Thiazolidinone	Inhibitor	/	Unkown
HY-RS04149	ECT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04150	ECT2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22150	Ect2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28671	Ect2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ECT2	VGNC	VGNC:72152
Felis catus	ECT2	VGNC	VGNC:61716
Bos taurus	ECT2	VGNC	VGNC:28314
Rattus norvegicus	ECT2	RGD	RGD:1308524
Canis familiaris	ECT2	VGNC	VGNC:40189
Mus musculus	ECT2	MGD	MGI:95281
Others	ECT2	NCBI