1. Cell Cycle/DNA Damage
  2. APC
  3. proTAME

proTAME 

Cat. No.: HY-124955
Handling Instructions

proTAME, a cell-permeable prodrug form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase.

For research use only. We do not sell to patients.

proTAME Chemical Structure

proTAME Chemical Structure

CAS No. : 1362911-19-0

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Description

proTAME, a cell-permeable prodrug form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase[1][2].

In Vitro

ProTAME prevents anaphase entry in mouse and bovine oocytes and also in mouse 2-cell embryos. proTAME (0-100 μM ) treatment shows dose-dependent metaphase arrest in mammalian oocytes and early cleavage embryos. And the metaphase arrest induced by this drug does not require spindle assembly checkpoint (SAC) activity[1].
ProTAME arrest of meiosis I in mouse oocytes is due to the inhibition of APC/C. In contrast to the somatic cells, the arrest in oocytes and embryos is not reversible[1].
proTAME (0-20 μM) dose-dependently affects morphological parameters of the spindle in oocytes and in embryos[1].
proTAME is efficient in overcoming resistance caused by the hyperphosphorylation of CDH1 in glioblastoma cells, polo-like kinase 1 (PLK1)-based drug resistance in ovarian cancer cells and CDC20-based resistance in diffuse large B-cell lymphoma[1].
proTAME inhibits OVCAR-3 cells growth with an IC50 of 12.5 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

726.75

Formula

C₃₄H₃₈N₄O₁₂S

CAS No.
SMILES

O=C(CC1=CC=CC=C1)OCOC(N/C(NC(OCOC(CC2=CC=CC=C2)=O)=O)=N/CCC[[email protected]@H](C(OC)=O)NS(=O)(C3=CC=C(C=C3)C)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

proTAMEAPCAnaphase promoting complexcell-permeablemetaphasecellcycle spindleassemblycheckpointInhibitorinhibitorinhibit

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proTAME
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