1362911-19-0
1362911-19-0
Chemical Structure
proTAME
- CAS No.: 1362911-19-0
- Formula:C34H38N4O12S
- Molecular Weight:726.75
IUPAC Name: (S)-5-((5-methoxy-4-((4-methylphenyl)sulfonamido)-5-oxopentyl)imino)-3,7-dioxo-2,8-dioxa-4,6-diazanonane-1,9-diyl bis(2-phenylacetate)
InChIKey: MHYOVHULCQSDRZ-NDEPHWFRSA-N
SMILES: O=C(CC1=CC=CC=C1)OCOC(N/C(NC(OCOC(CC2=CC=CC=C2)=O)=O)=N/CCC[C@@H](C(OC)=O)NS(=O)(C3=CC=C(C=C3)C)=O)=O
Biological Activity: proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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proTAME | 98.33% | proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase. | ||||||||||||||||||||
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References
- [1]. Lenka Radonova, et al. ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity. Int J Mol Sci. 2019 Sep 13;20(18):4537. [Content Brief]
- [2]. Monika Raab, et al. Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability. Neoplasia. 2019 Apr;21(4):363-375. [Content Brief]
