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Cat. No.: HY-161707

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MMP2-IN-4

MMP2-IN-4 (compound 3h) is a potent MMP2 inhibitor. MMP2-IN-4 inhibits MMP2, MMP9 and MMP12 with IC₅₀s of 266.74, 402.75 and 1237.39 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 92535-43-8
Formula: C₁₉H₂₂N₂O₅S
Molecular Weight:390.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MMP2-IN-4 Chemical Structure

CAS No.: 92535-43-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

MMP2-IN-4 (compound 3h) is a potent MMP2 inhibitor. MMP2-IN-4 inhibits MMP2, MMP9 and MMP12 with IC₅₀s of 266.74, 402.75 and 1237.39 nM, respectively^[1].

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.57 μM Compound: 3h'	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
ACHN	IC₅₀	17.15 μM Compound: 3h'	Antiproliferative activity against human ACHN cells incubated for 72 hrs by MTT assay Antiproliferative activity against human ACHN cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
HEK293	IC₅₀	292.73 μM Compound: 3h'	Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
HT-1080	IC₅₀	19.67 μM Compound: 3h'	Antiproliferative activity against human HT-1080 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells incubated for 72 hrs by MTT assay	[PMID: 38843586]
K562	IC₅₀	1.99 μM Compound: 3h'	Antiproliferative activity against human K562 cells incubated for 72 hrs by PrestoBlue assay Antiproliferative activity against human K562 cells incubated for 72 hrs by PrestoBlue assay	[PMID: 38843586]
U-87MG ATCC	IC₅₀	17.53 μM Compound: 3h'	Antiproliferative activity against human U-87 MG cells incubated for 72 hrs by MTT assay Antiproliferative activity against human U-87 MG cells incubated for 72 hrs by MTT assay	[PMID: 38843586]

Chemical Information

CAS No. 92535-43-8
Molecular Weight 390.45
Formula C₁₉H₂₂N₂O₅S
SMILES

CC1=CC=C(S(N[C@@H](C(O)=O)CCC(NCC2=CC=CC=C2)=O)(=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Das S, et al. Derivatives of D(-) glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-I: Synthesis, biological screening and in silico binding interaction analysis. Eur J Med Chem. 2024 Aug 5;274:116563. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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