2. Gene
  3. SPATA13 - spermatogenesis associated 13 Gene

SPATA13 - spermatogenesis associated 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ASEF2; ARHGEF29

Gene ID: 221178 | Gene type: protein coding

About SPATA13

Cytogenetic location: 13q12.12 Genomic coordinates (GRCh38): 13:23,979,802-24,307,069 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 22.0), lymph node (RPKM 7.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPATA13 Products(6)

mRNA Protein Name
NM_001166271.3 NP_001159743.1 spermatogenesis-associated protein 13 isoform 1
NM_001286792.2 NP_001273721.1 spermatogenesis-associated protein 13 isoform 3
NM_001286793.2 NP_001273722.1 spermatogenesis-associated protein 13 isoform 4
NM_001286794.2 NP_001273723.1 spermatogenesis-associated protein 13 isoform 5
NM_001286795.2 NP_001273724.1 spermatogenesis-associated protein 13 isoform 6
NM_153023.4 NP_694568.1 spermatogenesis-associated protein 13 isoform 2

SPATA13 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (154 - 201)

RhoGEF

RhoGEF: RhoGEF domain (244 - 423)

PH

PH: PH domain (457 - 555)

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  • 652 a.a.
Protein Preferred Names Protein Names

spermatogenesis-associated protein 13

APC-stimulated guanine nucleotide exchange factor 2

Related Diseases

Diseases Alias
Optic Atrophy 3, Autosomal Dominant

Optic Atrophy 3

OPA3

Autosomal Dominant Optic Atrophy And Cataract

Optic Atrophy And Cataract, Autosomal Dominant

Autosomal Dominant Optic Atrophy Type 3

Optic Atrophy 3 With Cataract

Opa3, Autosomal Dominant

Adoac

Optic Atrophy, Cataract, And Neurologic Disorder

Autosomal Dominant Optic Atrophy 3

Optic Atrophy Type 3

Optic Atrophy 3 Autosomal Dominant

Atrophy, Optic, Type 3, Autosomal Dominant

3-Methylglutaconic Aciduria Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13636 SPATA13 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPATA13 MGD MGI:104838
Rattus norvegicus SPATA13 RGD RGD:1307364