CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

Also Known as HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57105

About CYSLTR2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,653,929-48,711,226 (from NCBI)

This gene has 6 transcripts (splice variants), 80 orthologues, 16 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues.

Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

CYSLTR2 Products (11)

mRNA Protein Name
NM_001308476.3 NP_001295405.1 cysteinyl leukotriene receptor 2
NM_020377.5 NP_065110.1 cysteinyl leukotriene receptor 2
NM_001387013.1 NP_001373942.1 cysteinyl leukotriene receptor 2
NM_001308465.3 NP_001295394.1 cysteinyl leukotriene receptor 2
NM_001308468.3 NP_001295397.1 cysteinyl leukotriene receptor 2
NM_001308467.3 NP_001295396.1 cysteinyl leukotriene receptor 2
NM_001387014.1 NP_001373943.1 cysteinyl leukotriene receptor 2
NM_001308469.3 NP_001295398.1 cysteinyl leukotriene receptor 2
NM_001308471.3 NP_001295400.1 cysteinyl leukotriene receptor 2
NM_001308470.3 NP_001295399.1 cysteinyl leukotriene receptor 2
NM_001387012.1 NP_001373941.1 cysteinyl leukotriene receptor 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21525870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYSLTR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (55 - 305)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 2

  • G-protein coupled receptor GPCR21

  • G-protein coupled receptor HG57

  • cysteinyl leukotriene CysLT2 receptor

CYSLTR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
TAP
26617989
Intra
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
Ub Reconstruction
21525870
Intra
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Conjunctival Cancer

  • Malignant Neoplasm Of Conjunctiva

  • Conjunctival Neoplasms

  • Conjunctival Tumor

  • Malignant Conjunctival Tumor

  • Malignant Tumor Of Conjunctiva

  • Neoplasm Of Conjunctiva

  • Conjunctiva Cancer

  • Primary Malignant Neoplasm Of Conjunctiva
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Malignant Conjunctival Melanoma

  • Conjunctival Melanoma

  • Malignant Melanoma Of Conjunctiva

  • Conjunctival Malignant Melanoma
Vernal Conjunctivitis

  • Conjunctivitis Vernal

  • Conjunctivitis, Vernal
Asthma, Nasal Polyps, And Aspirin Intolerance

  • Asthma And Nasal Polyps

  • Asa Triad

  • Asthma, Aspirin-Induced, Susceptibility To

  • Asthma, Aspirin-Induced

  • Asthma, With Nasal Polyps And Aspirin Intolerance

  • ANPAI

  • Aia

  • Aspirin-Intolerant Asthma

  • Asthma Aspirin-Induced

  • Nasal Polyps Asthma And Aspirin Sensitivity

  • Samter Triad

  • Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Aspirin-Induced Respiratory Disease

  • Aspirin-Sensitive Asthma
Persistent Mild Asthma
Exercise-Induced Bronchoconstriction

  • Exercise-Induced Asthma

  • Asthma Exercise-Induced
Ocular Melanoma

  • Intraocular Melanoma

  • Uveal Melanoma

  • Eye Melanoma

  • Melanoma Of Eye

  • Melanoma Of The Uvea

  • Malignant Melanoma Of Eye
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Uveal Disease

  • Uveal Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYSLTR2 MGD MGI:1917336
Bos taurus CYSLTR2 VGNC VGNC:50271
Macaca mulatta CYSLTR2 VGNC VGNC:106256
Rattus norvegicus CYSLTR2 RGD RGD:619797
Canis familiaris CYSLTR2 VGNC VGNC:57504
Others CYSLTR2 NCBI