JNK-IN-24
JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers.
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- CAS No.: 2226808-28-0
- Formule: C19H17ClO5
- Masse moléculaire:360.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vivo
JNK-IN-24 (250-1000 μM, incorporated into a corn agar-based food medium, 36 h) rescues early pupal deaths to fully differentiated into pharate adults and promotes recovery from tumorous wing disc phenotype of ScribRNAi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Knockdown Scrib in wing imaginal discs[1]
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Dosage:250, 1000 μM
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Administration:Incorporated into a corn agar-based food medium for 36 h
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Result:Exhibited significantly reduced Scrib transcript levels.
Decreased the levels of JNK and MMP1.
Restricted cancer cell migration from across anterior to posterior boundary.
Chemical Information
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CAS No. 2226808-28-0
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Masse moléculaire 360.79
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Formule C19H17ClO5
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SMILES
O=C(C1=C(C)OC2=C(C(O)=CC(O)=C2)C1C3=CC=C(Cl)C=C3)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-IN-24 Related Classifications
HY-175276 Related Classifications
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