JNK-IN-24
JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers.
For research use only. We do not sell to patients.
- CAS No.: 2226808-28-0
- Formula: C19H17ClO5
- Molecular Weight:360.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
JNK-IN-24 (250-1000 μM, incorporated into a corn agar-based food medium, 36 h) rescues early pupal deaths to fully differentiated into pharate adults and promotes recovery from tumorous wing disc phenotype of ScribRNAi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Knockdown Scrib in wing imaginal discs[1]
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Dosage:250, 1000 μM
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Administration:Incorporated into a corn agar-based food medium for 36 h
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Result:Exhibited significantly reduced Scrib transcript levels.
Decreased the levels of JNK and MMP1.
Restricted cancer cell migration from across anterior to posterior boundary.
Chemical Information
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CAS No. 2226808-28-0
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Molecular Weight 360.79
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Formula C19H17ClO5
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SMILES
O=C(C1=C(C)OC2=C(C(O)=CC(O)=C2)C1C3=CC=C(Cl)C=C3)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-IN-24 Related Classifications
HY-175276 Related Classifications
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