FASTKD5 - FAST kinase domains 5 Gene

Also Known as dJ1187M17.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60493

About FASTKD5

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,146,519-3,159,865 (from NCBI)

This gene has 5 transcripts (splice variants), 147 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), adrenal (RPKM 8.0) and 25 other tissues.

Summary

Enables rRNA binding activity. Involved in mitochondrial RNA processing. Located in mitochondrial nucleoid and ribonucleoprotein granule. [provided by Alliance of Genome Resources, Apr 2022]

FASTKD5 Products (1)

mRNA Protein Name
NM_021826.5 NP_068598.1 FAST kinase domain-containing protein 5, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables rRNA binding IDA
IDA: Inferred from direct assay
25683715 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial RNA processing IMP
IMP: Inferred from mutant phenotype
25683715 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
25683715 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
20869947 GOA
located in ribonucleoprotein granule IDA
IDA: Inferred from direct assay
25683715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FASTKD5 Protein Structure

FAST_1

FAST_1: FAST kinase-like protein, subdomain 1 (430 - 500)

FAST_2

FAST_2: FAST kinase-like protein, subdomain 2 (511 - 602)

RAP

RAP: RAP domain (701 - 758)

  • 0
  • 200
  • 400
  • 600
  • 764 a.a.
Protein Preferred Names Protein Names

FAST kinase domain-containing protein 5, mitochondrial

FASTKD5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FASTKD5 Q7L8L6 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
FASTKD5 Q7L8L6 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
FASTKD5 Q7L8L6 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
FASTKD5 Q7L8L6 KCNH1 Homo sapiens O95259
Y2H Array
25416956
Intra
FASTKD5 Q7L8L6 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
FASTKD5 Q7L8L6 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
FASTKD5 Q7L8L6 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
FASTKD5 Q7L8L6 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
FASTKD5 Q7L8L6 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mitochondrial Dna Depletion Syndrome 4b

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome

  • Mngie Syndrome

  • Thymidine Phosphorylase Deficiency

  • MTDPS4B

  • Mitochondrial Neurogastrointestinal Encephalopathy Disease

  • Mngie

  • Myoneurogastrointestinal Encephalopathy Syndrome

  • Ogimd

  • Oculogastrointestinal Muscular Dystrophy

  • Polip

  • Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related

  • Mngie, Polg-Related

  • Mepop

  • Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction

  • Mngie Disease

  • Mitochondrial Dna Depletion Syndrome 4b Mngie Type

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related

  • Mngie Polg-Related

  • Mitochondrial Dna Depletion Syndrome, Type 4b

  • Visceral Myopathy Familial External Ophthalmoplegia
Cardiomyopathy, Infantile Hypertrophic

  • Infantile Hypertrophic Cardiomyopathy

  • CMHI
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04759 FASTKD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FASTKD5 VGNC VGNC:106736
Mus musculus FASTKD5 MGD MGI:2139469
Macaca mulatta FASTKD5 VGNC VGNC:84767
Rattus norvegicus FASTKD5 RGD RGD:1563839
Canis familiaris FASTKD5 VGNC VGNC:40741
Others FASTKD5 NCBI