CaMKII delta Antibody (YA2337)(PBS only)

Art. -Nr.: HY-P82592A: Data Sheet User Guide for Antibodies
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CaMKII delta Antibody (YA2337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII delta.

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Größe		Verfügbarkeit
50 μL		Angebot einholen
100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

CaMKII delta Antibody (YA2337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII delta.

Host

Rabbit

Molekulargewicht

Predicted band size: 56 kDa;

Observed band size: 56 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

Q13557

Gene ID

817 [NCBI]

Immunogen

A synthetic peptide of human CaMKII delta

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Reinheit	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)

Subcellular Localization：Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side; Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side

Expression：
Tissue_specificity:It is expressed in both cardiac and skeletal muscle. The Δ3, Δ2, Δ8, and Δ9 isoforms are expressed in cardiac muscle. The Δ11 isoform is expressed in skeletal muscle.

Induction:Activity is induced in skeletal muscle during exercise

Isoforms & Post-Translational Modification：Q13557 has 10 isomers: Q13557-1: 56369 Da (predicted); Q13557-3: 57620 Da (predicted); Q13557-4: 58472 Da (predicted); Q13557-8: 54128 Da (predicted); Q13557-9: 55378 Da (predicted); Q13557-5: 56230 Da (predicted); Q13557-6: 57901 Da (predicted); Q13557-10: 55660 Da (predicted); Q13557-11: 59152 Da (predicted); Q13557-12: 54114 Da (predicted).
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state

Subunit：CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D).

Research Field

Neuroscience

Synonyms

CAM kinase 2 delta; CAM kinase II delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CAMK 2d; CaMK-II delta subunit; CAMK2D; CAMKI

Dokumentation

User Guide for Antibodies (1077 KB)