MOAP1 - modulator of apoptosis 1 Gene

Also Known as MAP-1; PNMA4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64112

About MOAP1

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,182,199-93,184,897 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 565 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 65.7), heart (RPKM 21.0) and 24 other tissues.

Summary

The protein encoded by this gene was identified by its interaction with Apoptosis regulator Bax protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with Bax. When overexpressed, this gene has been shown to mediate caspase-dependent Apoptosis. [provided by RefSeq, Jul 2008]

MOAP1 Products (1)

mRNA Protein Name
NM_022151.5 NP_071434.2 modulator of apoptosis 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11060313 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
19100260 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
11060313 GOA
involved in extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
16199525 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
16199525 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
16199525 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15949439 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
33783314 GOA
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
16199525 GOA
involved in protein insertion into mitochondrial membrane IMP
IMP: Inferred from mutant phenotype
16199525 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19100260 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
16199525 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
19100260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOAP1 Protein Structure

PNMA

PNMA: PNMA (1 - 326)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

modulator of apoptosis 1

  • MAP1

MOAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MOAP1 Q96BY2 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra
MOAP1 Q96BY2 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Intra
MOAP1 Q96BY2 LATS1 Homo sapiens Q6PJG3
Y2H Array
25416956
Intra
MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
MOAP1 Q96BY2 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
MOAP1 Q96BY2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Validated Y2H
32296183
Intra
MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 THOC1 Homo sapiens Q96FV9
Y2H Array
32296183
Intra
MOAP1 Q96BY2 PPP2R3C Homo sapiens Q969Q6
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 PPP2R3C Homo sapiens Q969Q6
Y2H Array
32296183
Intra
MOAP1 Q96BY2 CAMK2D Homo sapiens Q13557
Validated Y2H
25416956
Intra
MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
MOAP1 Q96BY2 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
MOAP1 Q96BY2 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08572 MOAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MOAP1 MGD MGI:1915555
Rattus norvegicus MOAP1 RGD RGD:1307230
Felis catus MOAP1 VGNC VGNC:104513
Macaca mulatta MOAP1 VGNC VGNC:84392
Others MOAP1 NCBI