PPP2R3C - protein phosphatase 2 regulatory subunit B''gamma Gene

Also Known as G4-1; G5pr; GDRM; MEGD; SPGF36; C14orf10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55012

About PPP2R3C

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,085,472-35,122,298 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 18.2), bone marrow (RPKM 7.6) and 24 other tissues.

Summary

This gene encodes a regulatory subunit of the serine/threonine Phosphatase, protein Phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its Phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PPP2R3C Products (3)

mRNA	Protein	Name
NM_001305155.2	NP_001292084.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2
NM_001305156.2	NP_001292085.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2
NM_017917.4	NP_060387.2	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma	protein phosphatase 2 (formerly 2A), regulatory subunit B''

PPP2R3C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R3C	Q969Q6	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	PPP2R3C	Q969Q6	POLR1C	Homo sapiens	O15160	Y2H Array	25416956
Intra	PPP2R3C	Q969Q6	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
Intra	PPP2R3C	Q969Q6	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956
Intra	PPP2R3C	Q969Q6	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	PPP2R3C	Q969Q6	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	PPP2R3C	Q969Q6	SMG9	Homo sapiens	Q9H0W8	Validated Y2H	32296183
Intra	PPP2R3C	Q969Q6	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	PPP2R3C	Q969Q6	MOAP1	Homo sapiens	Q96BY2	Validated Y2H	32296183
Intra	PPP2R3C	Q969Q6	RTN3	Homo sapiens	O95197	Validated Y2H	25416956
Intra	PPP2R3C	Q969Q6	RTN3	Homo sapiens	O95197	Y2H Prey Pooling	25416956
Intra	PPP2R3C	Q969Q6	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure 36	SPGF36
Myoectodermal Gonadal Dysgenesis Syndrome	Gonadal Dysgenesis, Dysmorphic Facies, Retinal Dystrophy, And Myopathy GDRM MEGD Brosnan-Kennerknecht-Guran-Koc Syndrome Bkgk
Gonadal Dysgenesis	Gonadal Dysgenesis Syndrome Turner Syndrome
Late Congenital Syphilis	Juvenile Neurosyphilis Neurosyphilis, Juvenile
Omphalocele	Omphalocoele Congenital Omphalocele Exomphalos Exumbilication
Spastic Paraplegia 9b, Autosomal Recessive	SPG9B Autosomal Recessive Complex Spastic Paraplegia Type 9b Hereditary Spastic Paraplegia 9b Autosomal Recessive Spastic Paraplegia 9b Autosomal Recessive Spastic Paraplegia Type 9b Ar-Spg9b
Spastic Paraplegia 9a, Autosomal Dominant	Hereditary Spastic Paraplegia 9a SPG9A Cataracts With Motor Neuronopathy, Short Stature, And Skeletal Abnormalities Ad-Spg9a Spastic Paraparesis-Amyopathy-Cataracts-Gastroesophageal Reflux Syndrome Spastic Paraparesis With Amyotrophy, Cataracts, And Gastroesophageal Reflux Autosomal Dominant Complex Spastic Paraplegia Type 9a Autosomal Dominant Spastic Paraplegia 9a Cataracts Motor Neuropathy-Short Stature-Skeletal Anomalies Syndrome Cataracts With Motor Neuronopathy, Short Stature And Skeletal Abnormalities Spastic Paraparesis With Amyopathy, Cataracts And Gastroesophageal Reflux Autosomal Dominant Spastic Paraplegia Type 9a Cataracts-Motor Neuropathy-Short Stature-Skeletal Anomalies Syndrome Spastic Paraparesis With Amyopathy, Cataracts, And Gastroesophageal Reflux Spastic Paraplegia 9, Autosomal Dominant
Retinitis Pigmentosa 47	RP47 Retinitis Pigmentosa, Type 47
Skeletal Tuberculosis	Tuberculosis, Osteoarticular Osteoarticular Tuberculosis
Ovarian Endometrial Cancer	Endometrioid Neoplasm Of Ovary Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Neoplasm
Holoprosencephaly 8	HPE8 Holoprosencephaly-8
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11017	PPP2R3C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP2R3C	RGD	RGD:1309207
Macaca mulatta	PPP2R3C	VGNC	VGNC:76279
Mus musculus	PPP2R3C	MGD	MGI:1930009
Canis familiaris	PPP2R3C	VGNC	VGNC:44912
Bos taurus	PPP2R3C	VGNC	VGNC:33259
Felis catus	PPP2R3C	VGNC	VGNC:64327
Others	PPP2R3C	NCBI