ADAMTSL5 - ADAMTS like 5 Gene

Also Known as THSD6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339366

About ADAMTSL5

This gene has 11 transcripts (splice variants), 188 orthologues and 25 paralogues. Broad expression in endometrium (RPKM 3.3), heart (RPKM 2.8) and 21 other tissues.

Summary

Enables heparin binding activity and microfibril binding activity. Located in extracellular region and microfibril. [provided by Alliance of Genome Resources, Apr 2022]

ADAMTSL5 Products (2)

mRNA	Protein	Name
NM_001367197.1	NP_001354126.1	ADAMTS-like protein 5 isoform 1 precursor
NM_213604.3	NP_998769.2	ADAMTS-like protein 5 isoform 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparin binding	IDA IDA: Inferred from direct assay	23010571	GOA
enables microfibril binding	IDA IDA: Inferred from direct assay	23010571	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	23010571	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	23010571	GOA
located in microfibril	IDA IDA: Inferred from direct assay	23010571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTSL5 Protein Structure

TSP_1

ADAM_spacer1

NTR

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
ADAMTS-like protein 5	ADAMTSL-5

ADAMTSL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAMTSL5	Q6ZMM2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ADAMTSL5	Q6ZMM2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ADAMTSL5	Q6ZMM2	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	ADAMTSL5	Q6ZMM2	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	ADAMTSL5	Q6ZMM2	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	ADAMTSL5	Q6ZMM2	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Isolated Ectopia Lentis	Familial Ectopia Lentis Ectopia Lentis Ectopia Lentis Syndrome Lens Subluxation Iel Congenital Ectopia Lentis Subluxation Of Lens Ectopia Lentis, Isolated Ectopia Lentis Isolated
Autoimmune Lymphoproliferative Syndrome, Type Iii	ALPS3 Autoimmune Lymphoproliferative Syndrome Type 3 Immunodeficiency, Common Variable, 9, Formerly Cvid9, Formerly Autoimmune Lymphoproliferative Syndrome Type Iii Autoimmune Lymphoproliferative Syndrome 3 Cvid9 Immunodeficiency, Common Variable, 9 Type 3 Autoimmune Lymphoproliferative Syndrome Immunodeficiency, Variable, Common, Type 9
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00314	ADAMTSL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAMTSL5	RGD	RGD:1305607
Felis catus	ADAMTSL5	VGNC	VGNC:59603
Mus musculus	ADAMTSL5	MGD	MGI:1913798
Canis familiaris	ADAMTSL5	VGNC	VGNC:37609
Bos taurus	ADAMTSL5	VGNC	VGNC:106630
Macaca mulatta	ADAMTSL5	VGNC	VGNC:69540
Others	ADAMTSL5	NCBI