RAB26 - RAB26, member RAS oncogene family Gene

Also Known as V46133

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25837

About RAB26

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,148,144-2,154,165 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues and 68 paralogues. Broad expression in brain (RPKM 4.5), salivary gland (RPKM 3.5) and 15 other tissues.

Summary

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

RAB26 Products (2)

mRNA	Protein	Name
NM_001308053.1	NP_001294982.1	ras-related protein Rab-26 isoform 2
NM_014353.5	NP_055168.2	ras-related protein Rab-26 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GMP binding	IMP IMP: Inferred from mutant phenotype	23105096	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	23105096	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23105096	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	23105096	GOA
involved in exocrine system development	IMP IMP: Inferred from mutant phenotype	20038531	GOA
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	20038531	GOA
involved in regulation protein catabolic process at presynapse	IDA IDA: Inferred from direct assay	29084947	GOA
involved in regulation protein catabolic process at presynapse	IMP IMP: Inferred from mutant phenotype	29084947	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	23105096	GOA
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	25643395	GOA
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	25643395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB26 Protein Structure

Ras

0
100
200
256 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-26	Ras-related oncogene protein

RAB26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB26	Q9ULW5	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	RAB26	Q9ULW5	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	RAB26	Q9ULW5	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	RAB26	Q9ULW5	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	Anti Bait CoIP	23105096
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	Pull Down	23105096
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	BRET	23105096

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB26 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810981	RAB26 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spastic Paraplegia 15, Autosomal Recessive	SPG15 Kjellin Syndrome Hereditary Spastic Paraplegia 15 Spastic Paraplegia And Retinal Degeneration Autosomal Recessive Spastic Paraplegia Type 15 Hereditary Spastic Paraparesis Type 15 Spastic Paraplegia-Retinal Degeneration Syndrome Autosomal Recessive Spastic Paraplegia 15
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	DSMA4 Autosomal Recessive Lower Motor Neuron Disease With Childhood Onset Distal Spinal Muscular Atrophy Type 4 Autosomal Recessive Distal Spinal Muscular Atrophy Type 4 Distal Spinal Muscular Atrophy, Autosomal Recessive, 4 Atrophy, Muscular, Spinal, Distal, Autosomal Recessive, Type 4
Spinal Muscular Atrophy, Type Iv	SMA4 Spinal Muscular Atrophy, Adult Form Spinal Muscular Atrophy 4 Spinal Muscular Atrophy-4 Adult Spinal Muscular Atrophy Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive Proximal Spinal Muscular Atrophy Type 4 Sma Type 4 Sma Type Iv Sma-Iv Sma Iv Spinal Muscular Atrophy Adult Form Spinal Muscular Atrophy Proximal Adult Autosomal Recessive Spinal Muscular Atrophy Type Iv Atrophy, Muscular, Spinal, Type Iv Myelopathic Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11536	RAB26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB26	VGNC	VGNC:80677
Mus musculus	RAB26	MGD	MGI:2443284
Bos taurus	RAB26	VGNC	VGNC:33633
Macaca mulatta	RAB26	VGNC	VGNC:81526
Rattus norvegicus	RAB26	RGD	RGD:620890
Canis familiaris	RAB26	VGNC	VGNC:45266
Others	RAB26	NCBI