ADRA2B - adrenoceptor alpha 2B Gene

Also Known as FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151

About ADRA2B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,112,876-96,116,571 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

ADRA2B Products (1)

mRNA Protein Name
NM_000682.7 NP_000673.2 alpha-2B adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
17215105 GOA
enables epinephrine binding IDA
IDA: Inferred from direct assay
17215105 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16531006 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in activation of protein kinase B activity IDA
IDA: Inferred from direct assay
17215105 GOA
involved in adrenergic receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17215105 GOA
involved in receptor transactivation IDA
IDA: Inferred from direct assay
17215105 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
27901063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA2B Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (29 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
Protein Preferred Names Protein Names

alpha-2B adrenergic receptor

  • ADRA2B adrenergic, alpha-2B-, receptor

ADRA2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADRA2B P18089 RAB26 Homo sapiens Q9ULW5
Pull Down
23105096
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Familial Adult Myoclonic Epilepsy

  • Benign Adult Familial Myoclonus Epilepsy

  • Bafme

  • Benign Adult Familial Myoclonic Epilepsy

  • Fame

  • Familial Cortical Myoclonic Tremor And Epilepsy

  • Fcmte

  • Adcme

  • Autosomal Dominant Cortical Myoclonus And Epilepsy

  • Fam

  • Epilepsy, Myoclonic, Familial Adult

  • Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Mild Cognitive Impairment
Epilepsy, Familial Adult Myoclonic, 2

  • FAME2

  • Benign Adult Familial Myoclonic Epilepsy 2

  • Bafme2

  • Fcmte2

  • Adcme

  • Cortical Myoclonic Tremor With Epilepsy, Familial, 2

  • Cortical Myoclonus And Epilepsy, Autosomal Dominant

  • Familial Adult Myoclonic Epilepsy 2

  • Epilepsy, Myoclonic, Benign Adult Familial, Type 2

  • Autosomal Dominant Cortical Myoclonus And Epilepsy

  • Familial Cortical Myoclonic Tremor And Epilepsy 2

  • Epilepsy, Myoclonic, Familial Adult, Type 2
Resting Heart Rate, Variation In

  • Resting Heart Rate

  • Rhr

  • Resting Heart Rate, Variation
Coronary Restenosis
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00412 ADRA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADRA2B VGNC VGNC:37675
Mus musculus ADRA2B MGD MGI:87935
Macaca mulatta ADRA2B VGNC VGNC:69724
Felis catus ADRA2B VGNC VGNC:59656
Bos taurus ADRA2B VGNC VGNC:25696
Rattus norvegicus ADRA2B RGD RGD:2057
Others ADRA2B NCBI