2. Gene
  3. RGS20 - regulator of G protein signaling 20 Gene

RGS20 - regulator of G protein signaling 20 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RGSZ1; ZGAP1; gz-GAP; g(z)GAP

Gene ID: 8601 | Gene type: protein coding

About RGS20

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,851,795-53,959,304 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues and 23 paralogues. Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues.

Summary

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

RGS20 Products(5)

mRNA Protein Name
NM_001286673.2 NP_001273602.1 regulator of G-protein signaling 20 isoform c
NM_001286674.2 NP_001273603.1 regulator of G-protein signaling 20 isoform d
NM_001286675.2 NP_001273604.1 regulator of G-protein signaling 20 isoform e
NM_003702.4 NP_003693.2 regulator of G-protein signaling 20 isoform b
NM_170587.4 NP_733466.1 regulator of G-protein signaling 20 isoform a

RGS20 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (262 - 377)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 20

gz-selective GTPase-activating protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11917 RGS20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS20 MGD MGI:1929866
Macaca mulatta RGS20 VGNC VGNC:76735
Rattus norvegicus RGS20 RGD RGD:1586146
Bos taurus RGS20 VGNC VGNC:33919
Canis familiaris RGS20 VGNC VGNC:45530