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IRX6 - iroquois homeobox 6 Gene

Also Known as IRX7; IRX-3; IRXB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79190

About IRX6

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,324,203-55,330,756 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 6 paralogues. Biased expression in fat (RPKM 7.9), heart (RPKM 3.1) and 5 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within detection of visible light; negative regulation of transcription, DNA-templated; and retina morphogenesis in camera-type eye. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IRX6 Products (1)

mRNA	Protein	Name
NM_024335.3	NP_077311.2	iroquois-class homeodomain protein IRX-6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX6 Protein Structure

Homeobox_KN

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
iroquois-class homeodomain protein IRX-6	homeodomain protein IRXB3

IRX6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRX6	P78412	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	IRX6	P78412	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	IRX6	P78412	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	IRX6	P78412	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	IRX6	P78412	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	IRX6	P78412	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	IRX6	P78412	TBX19	Homo sapiens	O60806	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	TBX19	Homo sapiens	O60806	Y2H Array	32296183
Intra	IRX6	P78412	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	IRX6	P78412	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	IRX6	P78412	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	IRX6	P78412	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	IRX6	P78412	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	IRX6	P78412	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	IRX6	P78412	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	IRX6	P78412	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	MYL2	Homo sapiens	P10916	Y2H Array	32296183
Intra	IRX6	P78412	MYL2	Homo sapiens	P10916	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	IRX6	P78412	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	IRX6	P78412	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	IRX6	P78412	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183
Intra	IRX6	P78412	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Transient Refractive Change
Aniseikonia
Lateral Displacement Of Eye	Lateral Displacement Of Globe
Cycloplegia	Ciliary Muscle Paresis Cycloplegic Paralysis Of Accommodation Paresis Of Accommodation Visual Accommodation Paralysis Accommodation Paralysis Intrinsic Paralysis Of Eye Muscle Cycloplegic
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Eye Accommodation Disease
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Pulmonary Immaturity	Primary Atelectasis Of Newborn Primary Atelectasis, In Perinatal Period Primary Failure To Expand Terminal Respiratory Units Immature Lungs Primary Atelectasis Pulmonary Immaturity Nos Lung Lobe Hypoplasia, Associated With Short Gestation Lung Nonexpansion Premature Lungs Pulmonary Hypoplasia Associated With Short Gestation Failure Of Expansion Of Terminal Respiratory Units Primary Atelectasis Of Fetus Or Newborn Primary Atelectasis In Perinatal Period

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06925	IRX6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IRX6	VGNC	VGNC:42103
Mus musculus	IRX6	MGD	MGI:1927642
Macaca mulatta	IRX6	VGNC	VGNC:73598
Rattus norvegicus	IRX6	RGD	RGD:1564830
Felis catus	IRX6	VGNC	VGNC:62973
Bos taurus	IRX6	VGNC	VGNC:30290
Others	IRX6	NCBI