OLFM3 - olfactomedin 3 Gene

Also Known as NOE3; NOELIN3; OPTIMEDIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118427

About OLFM3

Cytogenetic location: 1p21.1 Genomic coordinates (GRCh38): 1:101,802,560-101,996,926 (from NCBI)

This gene has 6 transcripts (splice variants), 203 orthologues and 9 paralogues. Biased expression in brain (RPKM 5.4) and adrenal (RPKM 0.4).

Summary

Predicted to be involved in eye photoreceptor cell development. Predicted to be located in Golgi apparatus; extracellular space; and synapse. Predicted to be part of AMPA glutamate receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

OLFM3 Products (3)

mRNA Protein Name
NM_001288821.2 NP_001275750.1 noelin-3 isoform 1 precursor
NM_001288823.2 NP_001275752.1 noelin-3 isoform 3
NM_058170.4 NP_477518.2 noelin-3 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12019210 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM3 Protein Structure

Noelin-1

Noelin-1: Neurogenesis glycoprotein (46 - 145)

OLF

OLF: Olfactomedin-like domain (222 - 468)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

noelin-3

  • olfactomedin related ER localized protein 3

OLFM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OLFM3 Q96PB7 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
OLFM3 Q96PB7 STUB1 Homo sapiens Q9UNE7
Y2H Array
31515488
Intra
OLFM3 Q96PB7 STUB1 Homo sapiens Q9UNE7
Y2H Prey Pooling
25416956
Intra
OLFM3 Q96PB7 STUB1 Homo sapiens Q9UNE7
Validated Y2H
25416956
Intra
OLFM3 Q96PB7 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Renal Pelvis Carcinoma

  • Malignant Neoplasm Of Renal Pelvis

  • Malignant Tumor Of Renal Pelvis

  • Carcinoma Of Kidney Pelvis

  • Malignant Renal Pelvis Neoplasm

  • Renal Pelvis Cancer
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09772 OLFM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OLFM3 VGNC VGNC:32419
Canis familiaris OLFM3 VGNC VGNC:44114
Felis catus OLFM3 VGNC VGNC:63960
Mus musculus OLFM3 MGD MGI:2387329
Macaca mulatta OLFM3 VGNC VGNC:75426
Rattus norvegicus OLFM3 RGD RGD:628672
Others OLFM3 NCBI