country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184236

Copy Link Print Information

Cbl-b-IN-34

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human K_d of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 2925237-58-5
Formula: C₂₉H₃₂F₃N₅O₂
Molecular Weight:539.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cbl-b-IN-34 Chemical Structure

CAS No.: 2925237-58-5

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human K_d of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer^[1].

In Vitro

Cbl-b-IN-34 (Compound 33) binds purified Cbl-b with a K_d of 2.4 nM and exhibits 14-fold selectivity for Cbl-b over c-Cbl in SPR assays^[1].
Cbl-b-IN-34 induces IL-2 production in PBMCs with an EC₅₀ of 78 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Cbl-b-IN-34 (Compound 33) (45-200 mg/kg; p.o.; QD or BID for 7 days) achieves high TGIs (131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively) in mice CT-26 models^[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice (1×10⁵ CT26 was injected to establish a xenograft model)^[1]
Dosage:

45 mg/kg; 90 mg/kg; 200 mg/kg
Administration:

p.o.; QD or BID for 7 days
Result:

Exhibited no efficacy for 45 mg/kg BID or 90 mg/kg QD dose.
Achieved TGIs of 131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively.
Caused no body weight loss or
animal death at all doses.

Chemical Information

CAS No. 2925237-58-5
Molecular Weight 539.59
Formula C₂₉H₃₂F₃N₅O₂
SMILES

O=C1N(C2=CC=CC([C@@]3(C4=NN=CN4C)C[C@@H](OC)C3)=C2)CC5=C1C=C(CNC6(C)CCC6)C=C5C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liang J, et al. Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy. ACS Med Chem Lett. 2026;17(6):1258-1265. Published 2026 May 27. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote