Cbl-b-IN-34
Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human Kd of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2925237-58-5
- Formula: C29H32F3N5O2
- Molecular Weight:539.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Cbl-b-IN-34 (Compound 33) binds purified Cbl-b with a Kd of 2.4 nM and exhibits 14-fold selectivity for Cbl-b over c-Cbl in SPR assays[1].
Cbl-b-IN-34 induces IL-2 production in PBMCs with an EC50 of 78 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mice (1×105 CT26 was injected to establish a xenograft model)[1]
-
Dosage:45 mg/kg; 90 mg/kg; 200 mg/kg
-
Administration:p.o.; QD or BID for 7 days
-
Result:Exhibited no efficacy for 45 mg/kg BID or 90 mg/kg QD dose.
Achieved TGIs of 131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively.
Caused no body weight loss or
animal death at all doses.
Chemical Information
-
CAS No. 2925237-58-5
-
Molecular Weight 539.59
-
Formula C29H32F3N5O2
-
SMILES
O=C1N(C2=CC=CC([C@@]3(C4=NN=CN4C)C[C@@H](OC)C3)=C2)CC5=C1C=C(CNC6(C)CCC6)C=C5C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz