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Referencia número: HY-184236

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Cbl-b-IN-34

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human K_d of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer.

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No. CAS: 2925237-58-5
Fòrmula: C₂₉H₃₂F₃N₅O₂
Peso molecular:539.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cbl-b-IN-34 Chemical Structure

No. CAS: 2925237-58-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human K_d of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer^[1].

In Vitro

Cbl-b-IN-34 (Compound 33) binds purified Cbl-b with a K_d of 2.4 nM and exhibits 14-fold selectivity for Cbl-b over c-Cbl in SPR assays^[1].
Cbl-b-IN-34 induces IL-2 production in PBMCs with an EC₅₀ of 78 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cbl-b-IN-34 (Compound 33) (45-200 mg/kg; p.o.; QD or BID for 7 days) achieves high TGIs (131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively) in mice CT-26 models^[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice (1×10⁵ CT26 was injected to establish a xenograft model)^[1]
Dosage:

45 mg/kg; 90 mg/kg; 200 mg/kg
Administration:

p.o.; QD or BID for 7 days
Result:

Exhibited no efficacy for 45 mg/kg BID or 90 mg/kg QD dose.
Achieved TGIs of 131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively.
Caused no body weight loss or
animal death at all doses.

Chemical Information

No. CAS 2925237-58-5
Peso molecular 539.59
Fòrmula C₂₉H₃₂F₃N₅O₂
SMILES

O=C1N(C2=CC=CC([C@@]3(C4=NN=CN4C)C[C@@H](OC)C3)=C2)CC5=C1C=C(CNC6(C)CCC6)C=C5C(F)(F)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Liang J, et al. Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy. ACS Med Chem Lett. 2026;17(6):1258-1265. Published 2026 May 27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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