2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Cbl-b-IN-34

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human Kd of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer.

For research use only. We do not sell to patients.

Cbl-b-IN-34

Cbl-b-IN-34 Chemical Structure

CAS No. : 2925237-58-5

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Cbl-b-IN-34 Related Antibodies

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Description

Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human Kd of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer[1].

In Vitro

Cbl-b-IN-34 (Compound 33) binds purified Cbl-b with a Kd of 2.4 nM and exhibits 14-fold selectivity for Cbl-b over c-Cbl in SPR assays[1].
Cbl-b-IN-34 induces IL-2 production in PBMCs with an EC50 of 78 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cbl-b-IN-34 Related Antibodies
In Vivo

Cbl-b-IN-34 (Compound 33) (45-200 mg/kg; p.o.; QD or BID for 7 days) achieves high TGIs (131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively) in mice CT-26 models[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (1×105 CT26 was injected to establish a xenograft model)[1]
Dosage: 45 mg/kg; 90 mg/kg; 200 mg/kg
Administration: p.o.; QD or BID for 7 days
Result: Exhibited no efficacy for 45 mg/kg BID or 90 mg/kg QD dose.
Achieved TGIs of 131% for 90 mg/kg BID dose and 145% for 200 mg/kg QD dose, respectively.
Caused no body weight loss or
animal death at all doses.
Molecular Weight

539.59

Formula

C29H32F3N5O2
CAS No.
SMILES

O=C1N(C2=CC=CC([C@@]3(C4=NN=CN4C)C[C@@H](OC)C3)=C2)CC5=C1C=C(CNC6(C)CCC6)C=C5C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cbl-b-IN-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cbl-b-IN-342925237-58-5E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSPR assaysmiceIL-2tumor growthCbl-bTKB-LHR interfacec-Cblcolorectal cancerPBMCT-cell activationInhibitorinhibitorinhibit

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