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Cat. No.: HY-159608

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PROTAC Cbl-b-IN-1

PROTAC Cbl-b-IN-1 (compound 64) is a potent Cbl-b PROTAC degrader with a DC₅₀ of less than 30 nM. PROTAC Cbl-b-IN-1 can be used for cancer research.
(Pink: Cbl-b ligand (HY-159615); Blue: Cereblon ligand (HY-W797329); Black: linker (HY-159617)).

For research use only. We do not sell to patients.

CAS No.: 3035210-39-7
Formula: C₅₃H₆₅F₃N₁₂O₆
Molecular Weight:1023.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC Cbl-b-IN-1 Chemical Structure

CAS No.: 3035210-39-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PROTAC Cbl-b-IN-1 (compound 64) is a potent Cbl-b PROTAC degrader with a DC₅₀ of less than 30 nM. PROTAC Cbl-b-IN-1 can be used for cancer research^[1]. (Pink: Cbl-b ligand (HY-159615); Blue: Cereblon ligand (HY-W797329); Black: linker (HY-159617)).

IC₅₀ & Target^[1]

Cereblon

Cbl-b

All PROTACs Isoforms :

In Vitro

Cbl-b is an E3 ubiquitin-protein ligase, acting as a negative regulator of T cell activation. It can be utilized for studying diseases related to cell proliferation, particularly cancer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3035210-39-7
Molecular Weight 1023.16
Formula C₅₃H₆₅F₃N₁₂O₆
SMILES

OC=O.FC(F)(C1=CC(CN2CCN(CC2)CCN3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)=CN8C1=CN(C9=CC([C@H](C%10=NN=CN%10C)C%11CCC%11)=CC=C9)C8=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Preparation of imidazopyridine derivatives for treating disorders. World Intellectual Property Organization, WO2024077244 A1. 2024-04-11.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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