2. PROTAC
  3. Ligands for E3 Ligase
  4. (3S)Lenalidomide-5-Br

(3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinase. (3S)Lenalidomide-5-Br can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608).

For research use only. We do not sell to patients.

(3S)Lenalidomide-5-Br

(3S)Lenalidomide-5-Br Chemical Structure

CAS No. : 2829898-76-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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(3S)Lenalidomide-5-Br Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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Description

(3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinase. (3S)Lenalidomide-5-Br can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608)[1].

IC50 & TargetCereblon

Cereblon

 

Molecular Weight

323.15

Formula

C13H11BrN2O3
CAS No.
Appearance

Solid

Color

Gray to gray purple

SMILES

O=C1N([C@@H]2C(NC(CC2)=O)=O)CC3=CC(Br)=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (154.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0945 mL 15.4727 mL 30.9454 mL
5 mM 0.6189 mL 3.0945 mL 6.1891 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0945 mL 15.4727 mL 30.9454 mL 77.3635 mL
5 mM 0.6189 mL 3.0945 mL 6.1891 mL 15.4727 mL
10 mM 0.3095 mL 1.5473 mL 3.0945 mL 7.7363 mL
15 mM 0.2063 mL 1.0315 mL 2.0630 mL 5.1576 mL
20 mM 0.1547 mL 0.7736 mL 1.5473 mL 3.8682 mL
25 mM 0.1238 mL 0.6189 mL 1.2378 mL 3.0945 mL
30 mM 0.1032 mL 0.5158 mL 1.0315 mL 2.5788 mL
40 mM 0.0774 mL 0.3868 mL 0.7736 mL 1.9341 mL
50 mM 0.0619 mL 0.3095 mL 0.6189 mL 1.5473 mL
60 mM 0.0516 mL 0.2579 mL 0.5158 mL 1.2894 mL
80 mM 0.0387 mL 0.1934 mL 0.3868 mL 0.9670 mL
100 mM 0.0309 mL 0.1547 mL 0.3095 mL 0.7736 mL
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(3S)Lenalidomide-5-Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S)Lenalidomide-5-Br2829898-76-0Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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