PROTAC STING Degrader-2 

PROTAC STING Degrader-2 is a STING PROTAC degrader with a DC₅₀ of 0.53 μM. PROTAC STING Degrader-2 reduces the phosphorylation levels of TBK1 and IRF3. PROTAC STING Degrader-2 decreases the mRNA expression levels of IFN-β, CXCL10 and TNF-α, and blocks luciferase secretion. PROTAC STING Degrader-2 can be used in the research of autoimmune diseases^[1].

PROTAC STING Degrader-2 (Compound SD-02) (78 nM-20 μM; 24 h) dose-dependently degrades STING protein in THP1 cells, with a DC₅₀ of 0.53 μM and a Dmax of 56.65%^[1].
PROTAC STING Degrader-2 (0.25-2 μM; 24 h) dose-dependently inhibits SATE-3',3'-c-di-dAMP-induced phosphorylation of TBK1 and IRF3 in THP1 cells^[1].
PROTAC STING Degrader-2 (0.25-2 μM; 24 h) dose-dependently inhibits the mRNA expression of IFN-β, CXCL10 and TNF-α in THP1 cells induced by SATE-3',3'-c-di-dAMP^[1].
PROTAC STING Degrader-2 (24 h) inhibits SATE-3',3'-c-di-dAMP-induced STING pathway activation in THP-1 Lucia ISG cells, with an IC₅₀ of 604 nM^[1].
PROTAC STING Degrader-2 (24 h) exhibits no cytotoxicity against THP1, U937 or U2OS cells at concentrations that effectively degrade STING, and does not inhibit cell proliferation even at higher concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1463.67

C₇₄H₇₉FN₁₀O₁₅S₃

3023095-61-3

CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCNC(C4=CC=CC(S(=O)(N5C=C(C=CC5=O)C(NCCCCCC(OC6=C(C=C(C=C6)NC(C7=CC=C(C=C7)C8=CC=CC=C8)=O)NS(=O)(C9=CC=C(C=C9)F)=O)=O)=O)=O)=C4)=O)=O)=O)=O)O)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo Q, et al. Covalent PROTAC design method based on a sulfonyl pyridone probe. Chem Commun (Camb). 2024;60(6):686-689. Published 2024 Jan 16.  [Content Brief]