3023095-61-3
Chemical Structure
PROTAC STING Degrader-2
- CAS No.: 3023095-61-3
- Formula:C74H79FN10O15S3
- Molecular Weight:1463.67
InChIKey: RXNBROLBKMPODG-ABLHSHFVSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCNC(C4=CC=CC(S(=O)(N5C=C(C=CC5=O)C(NCCCCCC(OC6=C(C=C(C=C6)NC(C7=CC=C(C=C7)C8=CC=CC=C8)=O)NS(=O)(C9=CC=C(C=C9)F)=O)=O)=O)=O)=C4)=O)=O)=O)=O)O)=O)C
Biological Activity: PROTAC STING Degrader-2 is a STING PROTAC degrader with a DC50 of 0.53 μM. PROTAC STING Degrader-2 reduces the phosphorylation levels of TBK1 and IRF3. PROTAC STING Degrader-2 decreases the mRNA expression levels of IFN-β, CXCL10 and TNF-α, and blocks luciferase secretion. PROTAC STING Degrader-2 can be used in the research of autoimmune diseases[1].
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PROTAC STING Degrader-2 | PROTAC STING Degrader-2 is a STING PROTAC degrader with a DC50 of 0.53 μM. PROTAC STING Degrader-2 reduces the phosphorylation levels of TBK1 and IRF3. PROTAC STING Degrader-2 decreases the mRNA expression levels of IFN-β, CXCL10 and TNF-α, and blocks luciferase secretion. PROTAC STING Degrader-2 can be used in the research of autoimmune diseases. | |||||||||||||||||||||
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