Matairesinol monoglucoside
Based on 2 publication(s) in Google Scholar
Matairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection.
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- Pureza: 99.42%
- No. CAS: 34446-06-5
- Fòrmula: C26H32O11
- Peso molecular:520.53
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Matairesinol monoglucoside
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Actividad biológica
Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently inhibits HBV DNA, HBsAg, and HBeAg expression in AAV-HBV-infected mouse primary hepatocytes, with the strongest effects observed at 10 μM[1].
Matairesinol monoglucoside (5 μM; 3-12 h) time-dependently enhances IFN-α and IFN-β mRNA expression in AAV-HBV-infected mouse primary hepatocytes, with maximum effects at 12 hours[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β mRNA and protein expression in a time-dependent manner in AAV-HBV-infected mouse primary hepatocytes, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β mRNA and protein expression in a time-dependent manner in AAV-HBV-infected mouse Kupffer cells, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation[1].
Matairesinol monoglucoside (24 h) enhances STING-mediated activation of IFN-β and ISRE luciferase reporters in HEK293T cells, but has no effect on TBK1- or IRF3-mediated activation[1].
Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently increases STING mRNA expression in AAV-HBV-infected mouse primary hepatocytes and Kupffer cells, with the strongest effects observed at 10 μM[1].
Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently upregulates STING protein expression and increases phosphorylation of TBK1 and IRF3 in AAV-HBV-infected mouse primary hepatocytes after 24 hours of incubation[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse primary hepatocytes, but this effect is abolished in STING knockout mouse primary hepatocytes[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse Kupffer cells, but this effect is abolished in STING knockout mouse Kupffer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse primary hepatocytes
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Concentration:5 μM
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Incubation Time:3 h; 6 h; 9 h; 12 h
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Result:Time-dependently enhanced IFN-α and IFN-β mRNA expression.
Achieved maximum effects at 12 hours.
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Cell Line:AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
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Concentration:5 μM
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Incubation Time:6 h
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Result:Enhanced IFN-α and IFN-β mRNA expression in a time-dependent manner
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Cell Line:AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
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Concentration:5 μM
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Incubation Time:6 h
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Result:Enhances IFN-α and IFN-β protein expression in a time-dependent manner, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation.
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Cell Line:AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
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Concentration:2.5 μM; 5 μM; 10 μM
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Incubation Time:24 h
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Result:Dose-dependently increased STING mRNA expression.
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Cell Line:AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
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Concentration:2.5 μM; 5 μM; 10 μM
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Incubation Time:24 h
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Result:Dose-dependently upregulated STING protein expression and increased phosphorylation of TBK1 and IRF3.
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Cell Line:AAV-HBV-infected wild-type mouse Kupffer cells and STING knockout mouse Kupffer cells
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Concentration:5 μM
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Incubation Time:6 h
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Result:Enhanced IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse Kupffer cells, but this effect was abolished in STING knockout mouse Kupffer cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (8- to 10-week-old, wild-type, pretreated with MMG then infected with AAV-HBV via tail vein injection)[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose; 24 hours prior to viral infection
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Result:Reduced serum HBsBsAg, HBeAg, and HBV DNA levels significantly relative to control.
Increased serum levels of alanine aminotransferase (ALT), IFN-α, and IFN-β significantly relative to control.
Chemical Information
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No. CAS 34446-06-5
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Appearance Solid
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Peso molecular 520.53
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Fòrmula C26H32O11
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Color White to off-white
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SMILES
OC(C=C1)=C(OC)C=C1C[C@@H](C(OC2)=O)[C@H]2CC3=CC(OC)=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=C3
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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RSC Med Chem
The lignan compound matairesinol monoglucoside induces type I interferon production in HBV infection immunity by regulating STING signaling. [Abstract]2025 Oct 3. PMID: 41049788 -
Aging (Albany NY)
MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1. [Abstract]2022 Aug 29;14(16):6796-6808. PMID: 36040387
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lin M, et al. The lignan compound matairesinol monoglucoside induces type I interferon production in HBV infection immunity by regulating STING signaling. RSC Med Chem. Published online October 3, 2025. [Content Brief]
[2]. Koyama N, et al. Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice. J Agric Food Chem. 2006 Jul 12;54(14):4970-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Matairesinol monoglucoside Related Classifications
HY-N8107 Related Classifications
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