2. Immunology/Inflammation Anti-infection
  3. STING IFNAR HBV
  4. Matairesinol monoglucoside

Matairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection.

For research use only. We do not sell to patients.

Matairesinol monoglucoside

Matairesinol monoglucoside Chemical Structure

CAS No. : 34446-06-5

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Based on 2 publication(s) in Google Scholar

Matairesinol monoglucoside Related Antibodies

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Description

Matairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection[1][2].

In Vitro

Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently inhibits HBV DNA, HBsAg, and HBeAg expression in AAV-HBV-infected mouse primary hepatocytes, with the strongest effects observed at 10 μM[1].
Matairesinol monoglucoside (5 μM; 3-12 h) time-dependently enhances IFN-α and IFN-β mRNA expression in AAV-HBV-infected mouse primary hepatocytes, with maximum effects at 12 hours[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β mRNA and protein expression in a time-dependent manner in AAV-HBV-infected mouse primary hepatocytes, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β mRNA and protein expression in a time-dependent manner in AAV-HBV-infected mouse Kupffer cells, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation[1].
Matairesinol monoglucoside (24 h) enhances STING-mediated activation of IFN-β and ISRE luciferase reporters in HEK293T cells, but has no effect on TBK1- or IRF3-mediated activation[1].
Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently increases STING mRNA expression in AAV-HBV-infected mouse primary hepatocytes and Kupffer cells, with the strongest effects observed at 10 μM[1].
Matairesinol monoglucoside (2.5-10 μM; 24 h) dose-dependently upregulates STING protein expression and increases phosphorylation of TBK1 and IRF3 in AAV-HBV-infected mouse primary hepatocytes after 24 hours of incubation[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse primary hepatocytes, but this effect is abolished in STING knockout mouse primary hepatocytes[1].
Matairesinol monoglucoside (5 μM; 6 h) enhances IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse Kupffer cells, but this effect is abolished in STING knockout mouse Kupffer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Matairesinol monoglucoside Related Antibodies

Real Time qPCR[1]

Cell Line: mouse primary hepatocytes
Concentration: 5 μM
Incubation Time: 3 h; 6 h; 9 h; 12 h
Result: Time-dependently enhanced IFN-α and IFN-β mRNA expression.
Achieved maximum effects at 12 hours.

Real Time qPCR[1]

Cell Line: AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
Concentration: 5 μM
Incubation Time: 6 h
Result: Enhanced IFN-α and IFN-β mRNA expression in a time-dependent manner

ELISA Assay[1]

Cell Line: AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
Concentration: 5 μM
Incubation Time: 6 h
Result: Enhances IFN-α and IFN-β protein expression in a time-dependent manner, with significant increases observed at 6, 12, and 24 hours post-AAV-HBV stimulation.

Real Time qPCR[1]

Cell Line: AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
Concentration: 2.5 μM; 5 μM; 10 μM
Incubation Time: 24 h
Result: Dose-dependently increased STING mRNA expression.

Western Blot Analysis[1]

Cell Line: AAV-HBV-infected mouse primary hepatocytes and AAV-HBV-infected mouse Kupffer cells
Concentration: 2.5 μM; 5 μM; 10 μM
Incubation Time: 24 h
Result: Dose-dependently upregulated STING protein expression and increased phosphorylation of TBK1 and IRF3.

ELISA Assay[1]

Cell Line: AAV-HBV-infected wild-type mouse Kupffer cells and STING knockout mouse Kupffer cells
Concentration: 5 μM
Incubation Time: 6 h
Result: Enhanced IFN-α and IFN-β protein expression in AAV-HBV-infected wild-type mouse Kupffer cells, but this effect was abolished in STING knockout mouse Kupffer cells
In Vivo

Matairesinol monoglucoside (10 mg/kg; i.p.; single dose; 24 hours prior to viral infection) induces significant anti-HBV activity and enhances type I interferon production in AAV-HBV-infected C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (8- to 10-week-old, wild-type, pretreated with MMG then infected with AAV-HBV via tail vein injection)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose; 24 hours prior to viral infection
Result: Reduced serum HBsBsAg, HBeAg, and HBV DNA levels significantly relative to control.
Increased serum levels of alanine aminotransferase (ALT), IFN-α, and IFN-β significantly relative to control.
Molecular Weight

520.53

Formula

C26H32O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1)=C(OC)C=C1C[C@@H](C(OC2)=O)[C@H]2CC3=CC(OC)=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Matairesinol monoglucoside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Matairesinol monoglucoside34446-06-5STINGIFNARHBVStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptor Hepatitis B virushepatitis b virusmouse Kupffer cellsIRF3HEK293T cellsIFN-βC57BL/6 micemouse primary hepatocytesTBK1IFN-αInhibitorinhibitorinhibit

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