1. Anti-infection
  2. Influenza Virus
    HCV
  3. KIN101

KIN101 

Cat. No.: HY-126113
Handling Instructions

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.

For research use only. We do not sell to patients.

KIN101 Chemical Structure

KIN101 Chemical Structure

CAS No. : 610753-87-2

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Description

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].

IC50 & Target

IC50: 2 μM (influenza virus) and >5 μM (DNV)[1]

In Vitro

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1].
KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1].
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1].
KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].
KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2].

Western Blot Analysis[1]

Cell Line: MRC5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Caused a significant decrease in the NP protein abundance.

RT-PCR[1]

Cell Line: Huh7 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Showed a >1 log decrease in HCV RNA levels.
Molecular Weight

395.22

Formula

C₁₆H₁₁BrO₅S

CAS No.

610753-87-2

SMILES

O=C1C(C2=CC=C(Br)C=C2)=COC3=CC(OS(=O)(C)=O)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

KIN101KIN 101KIN-101Influenza VirusHCVHepatitis C virusIsoflavoneViralDenguevirusDNVRNAhepatitisCIRF-3broad-spectrumInhibitorinhibitorinhibit

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KIN101
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HY-126113
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