2. Anti-infection
  3. Influenza Virus
    HCV
  4. KIN101

KIN101 

Cat. No.: HY-126113 Purity: 99.36%
COA Handling Instructions

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.

For research use only. We do not sell to patients.

KIN101 Chemical Structure

KIN101 Chemical Structure

CAS No. : 610753-87-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 260 In-stock
Estimated Time of Arrival: December 31
100 mg USD 390 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].

IC50 & Target

IC50: 2 μM (influenza virus) and >5 μM (DNV)[1]
In Vitro

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1].
KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1].
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1].
KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].
KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MRC5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Caused a significant decrease in the NP protein abundance.

RT-PCR[1]

Cell Line: Huh7 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Showed a >1 log decrease in HCV RNA levels.
Molecular Weight

395.22

Appearance

Solid

Formula

C16H11BrO5S
CAS No.
SMILES

O=C1C(C2=CC=C(Br)C=C2)=COC3=CC(OS(=O)(C)=O)=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (105.43 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5302 mL 12.6512 mL 25.3024 mL
5 mM 0.5060 mL 2.5302 mL 5.0605 mL
10 mM 0.2530 mL 1.2651 mL 2.5302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.26 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

KIN101610753-87-2KIN 101KIN-101Influenza VirusHCVHepatitis C virusIsoflavoneViralDenguevirusDNVRNAhepatitisCIRF-3broad-spectrumInhibitorinhibitorinhibit

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