2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cyclic GMP sodium

Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation.

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Cyclic GMP sodium Chemical Structure

Cyclic GMP sodium Chemical Structure

CAS No. : 40732-48-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclic GMP sodium:

Cyclic GMP sodium Related Antibodies

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Description

Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

367.19

Formula

C10H11N5NaO7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4([O-])=O.[Na+]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (226.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7234 mL 13.6169 mL 27.2339 mL
5 mM 0.5447 mL 2.7234 mL 5.4468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7234 mL 13.6169 mL 27.2339 mL 68.0846 mL
5 mM 0.5447 mL 2.7234 mL 5.4468 mL 13.6169 mL
10 mM 0.2723 mL 1.3617 mL 2.7234 mL 6.8085 mL
15 mM 0.1816 mL 0.9078 mL 1.8156 mL 4.5390 mL
20 mM 0.1362 mL 0.6808 mL 1.3617 mL 3.4042 mL
25 mM 0.1089 mL 0.5447 mL 1.0894 mL 2.7234 mL
30 mM 0.0908 mL 0.4539 mL 0.9078 mL 2.2695 mL
40 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7021 mL
50 mM 0.0545 mL 0.2723 mL 0.5447 mL 1.3617 mL
60 mM 0.0454 mL 0.2269 mL 0.4539 mL 1.1347 mL
80 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8511 mL
100 mM 0.0272 mL 0.1362 mL 0.2723 mL 0.6808 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclic GMP sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic GMP40732-48-7Endogenous MetaboliteANPregulatorNOInhibitorinhibitorinhibit

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