1. Immunology/Inflammation
  2. STING
  3. cGAMP

cGAMP (Synonyms: Cyclic AMP-GMP; Cyclic GMP-AMP)

Cat. No.: HY-12512 Purity: 98.56%
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cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.

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cGAMP Chemical Structure

cGAMP Chemical Structure

CAS No. : 849214-04-6

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10 mM * 1 mL in Water USD 2448 In-stock
Estimated Time of Arrival: December 31
500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 330 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand. Target: in vitro: cGAMP induced IFNβ RNA robustly even at concentrations as low as 10 nM. cGAMP was much more potent than c-di-GMP in inducing IFNβ based on ELISA assays. cGAMP was also more potent than c-di-GMP and c-di-AMP in activating IRF3. cGAMP binds to and activates STING to trigger the downstream signaling cascades [1]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF) [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4]. in vivo: cGAMP can enhance the adaptive immune response to the model antigen ovalbumin in mice. cGAMP promotes antigen specific IgG and a balanced Th1/Th2 lymphocyte response in immunized mice [2].

Molecular Weight

674.41

Formula

C₂₀H₂₄N₁₀O₁₃P₂

CAS No.

849214-04-6

SMILES

O=P(O[[email protected]]1[[email protected]@H](O)[[email protected]](N2C=NC3=C2N=CN=C3N)O[[email protected]@H]1COP4(O)=O)(O)OC[[email protected]@H]5[[email protected]@H](O4)[[email protected]@H](O)[[email protected]](N6C=NC7=C6N=C(N)NC7=O)O5

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Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (29.66 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4828 mL 7.4139 mL 14.8278 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL
10 mM 0.1483 mL 0.7414 mL 1.4828 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.56%

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cGAMP
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