1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. STING
    Endogenous Metabolite
  3. cGAMP disodium

cGAMP disodium (Synonyms: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium)

Cat. No.: HY-110385 Purity: 99.22%
Handling Instructions

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

For research use only. We do not sell to patients.

cGAMP disodium Chemical Structure

cGAMP disodium Chemical Structure

CAS No. : 2407516-83-8

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500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 330 In-stock
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5 mg USD 1200 In-stock
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10 mg USD 1850 In-stock
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25 mg USD 3500 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

In Vitro

cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP disodium directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

cGAMP (5 µg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
Molecular Weight

718.37

Formula

C20H22N10Na2O13P2

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 180 mg/mL (250.57 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3920 mL 6.9602 mL 13.9204 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL
10 mM 0.1392 mL 0.6960 mL 1.3920 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
cGAMP disodium
Cat. No.:
HY-110385
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