2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. STING Endogenous Metabolite
  4. cGAMP disodium

cGAMP disodium  (Synonyms: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium)

Cat. No.: HY-110385 Purity: 99.34%
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cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

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cGAMP disodium Chemical Structure

cGAMP disodium Chemical Structure

CAS No. : 2407516-83-8

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500 μg USD 190 In-stock
1 mg USD 330 In-stock
5 mg USD 950 In-stock
10 mg USD 1520 In-stock
25 mg USD 3040 In-stock
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Based on 7 publication(s) in Google Scholar

Other Forms of cGAMP disodium:

cGAMP disodium Related Antibodies

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Description

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
? cGAMP disodium directly activates murine and human dendritic cells in vitro[2].
? On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
? cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cGAMP disodium Related Antibodies
In Vivo

cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
Molecular Weight

718.37

Formula

C20H22N10Na2O13P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@]1([C@H]([C@H](N6C=NC7=C6N=C(N)NC7=O)O2)O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 180 mg/mL (250.57 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3920 mL 6.9602 mL 13.9204 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (139.20 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.34%

COA (256 KB) RP-HPLC (207 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3920 mL 6.9602 mL 13.9204 mL 34.8010 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL 6.9602 mL
10 mM 0.1392 mL 0.6960 mL 1.3920 mL 3.4801 mL
15 mM 0.0928 mL 0.4640 mL 0.9280 mL 2.3201 mL
20 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7401 mL
25 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
30 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
40 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
50 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
60 mM 0.0232 mL 0.1160 mL 0.2320 mL 0.5800 mL
80 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
100 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3480 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cGAMP disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAMP disodium2407516-83-8Cyclic GMP-AMP disodium3',3'-cGAMP disodiumSTINGEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSsecond messengerantigencytosolic DNAinterferonsimmune mediatorsInhibitorinhibitorinhibit

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