2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. STING Endogenous Metabolite
  4. cGAMP diammonium

cGAMP diammonium  (Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium)

Cat. No.: HY-110385A Purity: 95.19%
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cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

For research use only. We do not sell to patients.

cGAMP diammonium Chemical Structure

cGAMP diammonium Chemical Structure

Size Price Stock Quantity
500 μg USD 190 In-stock
1 mg USD 330 In-stock
5 mg USD 950 In-stock
10 mg USD 1520 In-stock
25 mg USD 3040 In-stock
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Based on 7 publication(s) in Google Scholar

Other Forms of cGAMP diammonium:

cGAMP diammonium Related Antibodies

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Description

cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP diammonium directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cGAMP diammonium Related Antibodies
In Vivo

cGAMP (5 µg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
Molecular Weight

708.47

Formula

C20H30N12O13P2
Appearance

Solid

Color

White to off-white

SMILES

O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5.N.N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (141.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4115 mL 7.0575 mL 14.1149 mL
5 mM 0.2823 mL 1.4115 mL 2.8230 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (47.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4115 mL 7.0575 mL 14.1149 mL 35.2873 mL
5 mM 0.2823 mL 1.4115 mL 2.8230 mL 7.0575 mL
10 mM 0.1411 mL 0.7057 mL 1.4115 mL 3.5287 mL
15 mM 0.0941 mL 0.4705 mL 0.9410 mL 2.3525 mL
20 mM 0.0706 mL 0.3529 mL 0.7057 mL 1.7644 mL
25 mM 0.0565 mL 0.2823 mL 0.5646 mL 1.4115 mL
30 mM 0.0470 mL 0.2352 mL 0.4705 mL 1.1762 mL
40 mM 0.0353 mL 0.1764 mL 0.3529 mL 0.8822 mL
50 mM 0.0282 mL 0.1411 mL 0.2823 mL 0.7057 mL
60 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5881 mL
80 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4411 mL
100 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.3529 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cGAMP diammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAMP diammoniumCyclic GMP-AMP diammonium3',3'-cGAMP diammoniumSTINGEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSsecond messengerantigencytosolic DNAinterferonsimmune mediatorsInhibitorinhibitorinhibit

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