2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. STING Endogenous Metabolite
  4. cGAMP diammonium

cGAMP diammonium  (Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium)

Cat. No.: HY-110385A Purity: 96.63%
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cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

For research use only. We do not sell to patients.

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
500 μg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 26 publication(s) in Google Scholar

Other Forms of cGAMP diammonium:

cGAMP diammonium Related Antibodies

Top Publications Citing Use of Products

    cGAMP diammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321.  [Abstract]

    cGAMP accelerated calcium deposition in VSMCs.

    cGAMP diammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321.  [Abstract]

    cGAMP increased the calcium content in VSMCs.

    cGAMP diammonium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 4;15(1):10543.  [Abstract]

    cGAMP (2.5 or 10 μM, 24 h) increased OLFM4 protein expression in HGC-27 cells.

    cGAMP diammonium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 4;15(1):10543.  [Abstract]

    cGAMP (10 μM, 6, 12, and 24 h) increased OLFM4 mRNA expression in HGC-27 cells.

    cGAMP diammonium purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Jun;32(6):1167-1179.  [Abstract]

    cGAMP (0, 2, and 200 nM; 3 or 6 h) increased STING phosphorylation at 3 h with 200 nM, but not at 6 h in THP-1 cells.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    In Vitro

    cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
    cGAMP diammonium directly activates murine and human dendritic cells in vitro[2].
    On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
    cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    cGAMP diammonium Related Antibodies
    In Vivo

    cGAMP (5 μg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
    Dosage: 5 µg
    Administration: Nostril mucosal adjuvant
    Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
    Molecular Weight

    708.47

    Formula

    C20H30N12O13P2
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5.N.N
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (141.15 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4115 mL 7.0575 mL 14.1149 mL
    5 mM 0.2823 mL 1.4115 mL 2.8230 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 33.33 mg/mL (47.05 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4115 mL 7.0575 mL 14.1149 mL 35.2873 mL
    5 mM 0.2823 mL 1.4115 mL 2.8230 mL 7.0575 mL
    10 mM 0.1411 mL 0.7057 mL 1.4115 mL 3.5287 mL
    15 mM 0.0941 mL 0.4705 mL 0.9410 mL 2.3525 mL
    20 mM 0.0706 mL 0.3529 mL 0.7057 mL 1.7644 mL
    25 mM 0.0565 mL 0.2823 mL 0.5646 mL 1.4115 mL
    30 mM 0.0470 mL 0.2352 mL 0.4705 mL 1.1762 mL
    40 mM 0.0353 mL 0.1764 mL 0.3529 mL 0.8822 mL
    50 mM 0.0282 mL 0.1411 mL 0.2823 mL 0.7057 mL
    60 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5881 mL
    80 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4411 mL
    100 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.3529 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    cGAMP diammonium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    cGAMP diammoniumCyclic GMP-AMP diammonium 3',3'-cGAMP diammoniumSTINGEndogenous MetaboliteStimulator of Interferon GenesTMEM173MITAERISMPYSsecond messengerantigencytosolic DNAinterferonsimmune mediatorsInhibitorinhibitorinhibit

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