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  4. Cyclic GMP (TBAOH)

Cyclic GMP TBAOH is a tetra-n-butylammonium hydroxide (TBAOH) form of Cyclic GMP (HY-12512). Cyclic GMP is an endogenous second messenger that regulates a variety of cellular processes including apoptosis, vasodilation, and neurotransmission through the activation of signaling pathways such as Protein Kinase G in cells.

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Cyclic GMP (TBAOH) Chemical Structure

Cyclic GMP (TBAOH) Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclic GMP (TBAOH):

Cyclic GMP (TBAOH) Related Antibodies

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Description

Cyclic GMP TBAOH is a tetra-n-butylammonium hydroxide (TBAOH) form of Cyclic GMP (HY-12512). Cyclic GMP is an endogenous second messenger that regulates a variety of cellular processes including apoptosis, vasodilation, and neurotransmission through the activation of signaling pathways such as Protein Kinase G in cells[1].

Molecular Weight

604.68

Formula

C26H49N6O8P
Appearance

Solid

Color

White to off-white

SMILES

CCCC[N+](CCCC)(CCCC)CCCC.O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O.[OH-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (165.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6538 mL 8.2688 mL 16.5377 mL
5 mM 0.3308 mL 1.6538 mL 3.3075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6538 mL 8.2688 mL 16.5377 mL 41.3442 mL
5 mM 0.3308 mL 1.6538 mL 3.3075 mL 8.2688 mL
10 mM 0.1654 mL 0.8269 mL 1.6538 mL 4.1344 mL
15 mM 0.1103 mL 0.5513 mL 1.1025 mL 2.7563 mL
20 mM 0.0827 mL 0.4134 mL 0.8269 mL 2.0672 mL
25 mM 0.0662 mL 0.3308 mL 0.6615 mL 1.6538 mL
30 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3781 mL
40 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0336 mL
50 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8269 mL
60 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6891 mL
80 mM 0.0207 mL 0.1034 mL 0.2067 mL 0.5168 mL
100 mM 0.0165 mL 0.0827 mL 0.1654 mL 0.4134 mL
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Cyclic GMP (TBAOH) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic GMP (TBAOH)OthersInhibitorinhibitorinhibit

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