Norkurarinol 

Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1^[1][2]

Norkurarinol (10-30 μM; 18 h total with poly(I:C)) inhibits poly(I:C)-induced NF-κB/AP-1 activation in THP1-Blue-CD14 cells with an IC₅₀ of 20.9 μM^[1].
Norkurarinol (30 μM) suppresses rotavirus-induced mRNA expression of pro-inflammatory cytokines (TNF-α, IL-6) in TF-104 cells^[1].
Norkurarinol (10-60 μM; 2-6 h for THP-1, 24 h for TF-104) induces IRF3 phosphorylation and IFNβ mRNA expression in THP-1 cells, enhances poly(I:C)-induced IFNβ expression in THP-1 cells, and increases rotavirus-induced IFNβ expression in TF-104 cells^[1].
Norkurarinol (30 μM; 72 h during rotavirus infection) inhibits rotavirus KJ56-1 replication in TF-104 cells, reducing viral titer by over 5 logs^[1].
Norkurarinol (0.1-100 μM; 20 min) potently inhibits mushroom tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

442.50

C₂₅H₃₀O₇

52483-01-9

CC(C)(O)CC[C@@H](C(C)=C)CC1=C2C(C(C[C@@H](C3=C(C=C(C=C3)O)O)O2)=O)=C(C=C1O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Oh HM, et al. Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication. J Pharmacol Sci. 2012;118(2):161-170.  [Content Brief]

  [2]. Son JK, et al. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 2003;69(6):559-561.  [Content Brief]