Norkurarinol
Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC50 of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1
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- CAS 番号: 52483-01-9
- 分子式: C25H30O7
- 分子量:442.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
IC50 & Target
[1]|
p38 |
ERK1 |
ERK2 |
IL-6 |
mushroom Tyrosinase 2.1 μM (IC50) |
体外実験
Norkurarinol (10-30 μM; 18 h total with poly(I:C)) inhibits poly(I:C)-induced NF-κB/AP-1 activation in THP1-Blue-CD14 cells with an IC50 of 20.9 μM[1].
Norkurarinol (30 μM) suppresses rotavirus-induced mRNA expression of pro-inflammatory cytokines (TNF-α, IL-6) in TF-104 cells[1].
Norkurarinol (10-60 μM; 2-6 h for THP-1, 24 h for TF-104) induces IRF3 phosphorylation and IFNβ mRNA expression in THP-1 cells, enhances poly(I:C)-induced IFNβ expression in THP-1 cells, and increases rotavirus-induced IFNβ expression in TF-104 cells[1].
Norkurarinol (30 μM; 72 h during rotavirus infection) inhibits rotavirus KJ56-1 replication in TF-104 cells, reducing viral titer by over 5 logs[1].
Norkurarinol (0.1-100 μM; 20 min) potently inhibits mushroom tyrosinase DOPA oxidase activity with an IC50 of 2.1 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 cells
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Concentration:10-60 μM
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Incubation Time:2 h (with poly(I:C))
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Result:Inhibited poly(I:C)-induced nuclear translocation of NF-κB p65 and AP-1 subunit c-fos in a dose-dependent manner.
Inhibited poly(I:C)-induced phosphorylation of IκB, IKKα/β, IKKγ, p38, JNK, and ERK1/2 in a dose-dependent manner.
Increased poly(I:C)-induced phosphorylation of IRF3 in a dose-dependent manner.
化学情報
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CAS 番号 52483-01-9
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分子量 442.50
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分子式 C25H30O7
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SMILES
CC(C)(O)CC[C@@H](C(C)=C)CC1=C2C(C(C[C@@H](C3=C(C=C(C=C3)O)O)O2)=O)=C(C=C1O)O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Oh HM, et al. Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication. J Pharmacol Sci. 2012;118(2):161-170. [Content Brief]
[2]. Son JK, et al. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 2003;69(6):559-561. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Norkurarinol 関連分類
HY-N18197 関連分類
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