52483-01-9
Chemical Structure
Norkurarinol
- CAS No.: 52483-01-9
- Formula:C25H30O7
- Molecular Weight:442.50
InChIKey: PFTQIVMILQKDQN-PEBXRYMYSA-N
SMILES: CC(C)(O)CC[C@@H](C(C)=C)CC1=C2C(C(C[C@@H](C3=C(C=C(C=C3)O)O)O2)=O)=C(C=C1O)O
Biological Activity: Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC50 of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1[1][2]
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Norkurarinol | Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC50 of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1 | |||||||||||||||||||||
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- [1]. Oh HM, et al. Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication. J Pharmacol Sci. 2012;118(2):161-170. [Content Brief]
- [2]. Son JK, et al. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 2003;69(6):559-561. [Content Brief]
Keywords
