Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

  • Planta Med. 2003 Jun;69(6):559-61. doi: 10.1055/s-2003-40643.
Jong Keun Son  1 ,  Ji Soo Park ,  Jeong Ah Kim ,  Youngsoo Kim ,  See Ryun Chung ,  Seung Ho Lee
Affiliations
  • 1. College of Pharmacy, Yeungnam University, Kyongsan, Korea.
PMID: 12865979 DOI: 10.1055/s-2003-40643
Abstract

Prenylated Flavonoids containing the resorcinol moiety were isolated as Tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known Tyrosinase Inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

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