hSTING activator-1
hSTING activator-1 (Compound 68) is a STING agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with EC50 values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits fibrosarcoma tumor growth and has potential in cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C26H19FN4O2S
- Peso molecular:470.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Chemical Information
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Peso molecular 470.52
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Fòrmula C26H19FN4O2S
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SMILES
O=C(C1=CC=C(S[C@@H](C)C2=NN=C(C3=CC=C(F)C=C3)N24)C4=C1)NCC(O5)=CC6=C5C=CC=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hSTING activator-1 Related Classifications
HY-173399 Related Classifications
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