2. Immunology/Inflammation NF-κB
  3. STING IKK NF-κB IFNAR Interleukin Related
  4. UM-203

UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus.

For research use only. We do not sell to patients.

UM-203

UM-203 Chemical Structure

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UM-203 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus[1].

IC50 & Target[1]

TBK1

 

IL-6

 

Molecular Weight

552.67

Formula

C29H24N6O2S2
SMILES

O=C(C1=CN=C(C2=CC=CC=C2)S1)NC3(C4=NC5=CC=CC=C5N4C)CCN(C(C6=CSC(C#C)=N6)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UM-203 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UM-203UM203UM 203STINGIKKNF-κBIFNARInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBInterferon-α/β receptorInterferon-alpha/beta receptor ILInhibitorinhibitorinhibit

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