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Cat. No.: HY-178049

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UM-259

UM-259 is a STING inhibitor, with an EC₅₀ of 1.50 μM in THP1-Dual cells expressing wild-type STING. UM-259 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-259 can be used for the study of STING-dependent inflammatory and neurological diseases.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₁F₂N₇O₅
Molecular Weight:561.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

UM-259 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Interleukin Related Isoforms :

In Vitro

UM-259 (0.2-5 μM, pretreated for 1 h) exerts potent inhibitory activity on diABZI-induced IFNβ and IL6 gene transcription in iBMDMs^[1].
UM-259 (2.5 μM, pretreated for 1 h) displays potent activity in blocking STING-dependent IFNβ secretion in primary human CD14⁺ monocytes^[1].
UM-259 (5 μM, pretreated for 1 h) shows potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3and exhibits potent activity in inhibiting STING oligomerization in WT BMDMs, effectively blocking STING downstream signal transduction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

WT BMDMs
Concentration:

5 μM
Incubation Time:

Pretreated for 1 h
Result:

Showed potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3.
Exhibited potent activity in inhibiting STING oligomerization in WT BMDMs.

Chemical Information

Molecular Weight 561.50
Formula C₂₇H₂₁F₂N₇O₅
SMILES

O=C(C1=NOC(C2=CC=C(F)C=C2F)=C1)NC3(C4=NC5=CC=CC=C5N4)CCN(C(C6=CC=C([N+]([O-])=O)O6)=N)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10(36):41693-41706. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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