2. Cell Cycle/DNA Damage Apoptosis
  3. ClpP Apoptosis
  4. NCA029

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death.

For research use only. We do not sell to patients.

NCA029 Chemical Structure

NCA029 Chemical Structure

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NCA029 Related Antibodies

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Description

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death[1].

In Vitro

NCA029 inhibits human colon adenocarcinoma (COAD) cell lines with IC50 values of 1.1 μM, 1.5 μM, 3.5 μM, 5.4 μM, and 3.1 μM for HCT116, SW620, HCT15, SW480, and DLD-1, respectively[1].
NCA029 causes an increase in intracellular ROS levels in HCT116 cells in a dose-dependent manner, indicating impaired respiratory chain activity[1].
NCA029 (0.5-2 μM; 48 h) inhibits tumor cell proliferation and metastasis[1].
NCA029 (0.5-2 μM; 48 h) dose-dependently induces apoptosis and arrests cells with G2/M phase in HCT116 cells[1].
NCA029 (0.5-2 μM) dose-dependently reduces the expression of SDHB and up-regulated the expression of the pro-apoptotic protein BAX, while down-regulating the expression of the antiapoptotic protein Bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NCA029 Related Antibodies

Cell Migration Assay [1]

Cell Line: HCT116 cells
Concentration: 0.5 μM, 1 μM, 2 μM
Incubation Time: 48 h
Result: Resulted in a dose-dependent reduction in HCT116 clone formation ability.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 0.5 μM, 1 μM, 2 μM
Incubation Time: 48 h
Result: Significantly increased the number of cells in the G2 phase.
In Vivo

NCA029 (1.25-5 mg/kg; iv; twice weekly; for 21 days) significantly inhibits tumor growth in HCT116 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice bearing HCT116 tumors[1]
Dosage: 1.25, 2.5, and 5 mg/kg
Administration: intravenous administration; twice weekly; for 21 days
Result: Inhibited tumor growth in mice xenograft model.
Molecular Weight

399.41

Formula

C22H20F3N3O
SMILES

N#CC1=CC=CC(CN2CCC=C(C2)C(NCC3=CC=C(C=C3)C(F)(F)F)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NCA029 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCA029NCA 029NCA-029ClpPApoptosisCaseinolytic protease PHsClpP activatorcolon cancermitochondrial dysfunctionATF3Inhibitorinhibitorinhibit

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