1. PROTAC
    Apoptosis
  2. Ligand for E3 Ligase
    Apoptosis
  3. CC-90009

CC-90009 

Cat. No.: HY-130800 Purity: 99.51%
Handling Instructions

CC-90009 is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. CC-90009 coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.

For research use only. We do not sell to patients.

CC-90009 Chemical Structure

CC-90009 Chemical Structure

CAS No. : 1860875-51-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 91 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 91 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

CC-90009 is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. CC-90009 coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2].

IC50 & Target[1]

Cereblon

 

In Vitro

Depletion of GSPT1 by CC-90009 rapidly induces acute myeloid leukemia (AML) apoptosis, reducing leukemia engraftment and leukemia stem cells (LSCs) in large-scale primary patient xenografting of 35 independent AML samples. CC-90009 activity is mediated by multiple layers of signaling networks and pathways within AML blasts and LSCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.85

Formula

C₂₂H₁₈ClF₂N₃O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1652 mL 10.8260 mL 21.6521 mL
5 mM 0.4330 mL 2.1652 mL 4.3304 mL
10 mM 0.2165 mL 1.0826 mL 2.1652 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.51%

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Product Name:
CC-90009
Cat. No.:
HY-130800
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