Antiproliferative agent-23

Antiproliferative agent-23 (72 hours) has vitro antiproliferative effect in HepG2 (IC₅₀=0.86), MDA-MB-231 (IC₅₀=1.53), MCF-7 (IC₅₀=0.94), A2780 (IC₅₀=0.88), A549 (IC₅₀=0.23), A549/CDDP (IC₅₀=0.35), HepG2/CDDP (IC₅₀=1.16), HUEVC (IC₅₀=5.68)^[1].
Antiproliferative agent-23 (5 μM; 24 hours) effectively induces cell apoptosis in A549/CDDP cells^[1].
Antiproliferative agent-23 (5 μM; 24 hours) can efficiently cause DNA damage in A549/CDDP cells and thus ultimately triggered apoptosis. Antiproliferative agent-23 causes a significant increase in the ER stress-related protein expression^[1].
Antiproliferative agent-23 (10, 20 μM; 24 hours) leads to inhibitory effects of polymerization with an IC₅₀ of 9.86 μM^[1].
Antiproliferative agent-23 (5 μM; 24 hours) significantly increases intracellular ROS in A549/CDDP cells^[1].
Antiproliferative agent-23 (1 μM; 24 hours) potently inhibits A549 cell migration in in vitro assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.