Flurochloridone
Based on 1 Customer Validation
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 61213-25-0
- Formula: C12H10Cl2F3NO
- Molecular Weight:312.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Mitochondria-Targeted Compound Library
HY-L089
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Transcription Factor-Targeted Library
HY-L090
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Human Metabolite Library
HY-L123
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Osteogenesis Compound Library
HY-L131
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Pesticide Compound Library
HY-L183
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Environmental Pollutant Compound Library
HY-L247
Biological Activity
Chemical Information
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CAS No. 61213-25-0
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Appearance Solid
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Molecular Weight 312.12
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Formula C12H10Cl2F3NO
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Color Light yellow to brown
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SMILES
O=C1N(CC(C1Cl)CCl)C2=CC=CC(C(F)(F)F)=C2
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Synonyms
R-40244
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 175 mg/mL (560.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang F, et al. Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells. Int J Environ Res Public Health. 2022 Apr 11;19(8):4564. [Content Brief]
[2]. Nikoloff N, et al. Flurochloridone-based herbicides induced genotoxicity effects on Rhinella arenarum tadpoles (Anura: Bufonidae). Ecotoxicol Environ Saf. 2014 Feb;100:275-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2039 mL | 16.0195 mL | 32.0390 mL | 80.0974 mL |
| 5 mM | 0.6408 mL | 3.2039 mL | 6.4078 mL | 16.0195 mL | |
| 10 mM | 0.3204 mL | 1.6019 mL | 3.2039 mL | 8.0097 mL | |
| 15 mM | 0.2136 mL | 1.0680 mL | 2.1359 mL | 5.3398 mL | |
| 20 mM | 0.1602 mL | 0.8010 mL | 1.6019 mL | 4.0049 mL | |
| 25 mM | 0.1282 mL | 0.6408 mL | 1.2816 mL | 3.2039 mL | |
| 30 mM | 0.1068 mL | 0.5340 mL | 1.0680 mL | 2.6699 mL | |
| 40 mM | 0.0801 mL | 0.4005 mL | 0.8010 mL | 2.0024 mL | |
| 50 mM | 0.0641 mL | 0.3204 mL | 0.6408 mL | 1.6019 mL | |
| 60 mM | 0.0534 mL | 0.2670 mL | 0.5340 mL | 1.3350 mL | |
| 80 mM | 0.0400 mL | 0.2002 mL | 0.4005 mL | 1.0012 mL | |
| 100 mM | 0.0320 mL | 0.1602 mL | 0.3204 mL | 0.8010 mL |
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