61213-25-0
Chemical Structure
Flurochloridone
Synonym(s): R-40244
- CAS No.: 61213-25-0
- Formula:C12H10Cl2F3NO
- Molecular Weight:312.12
IUPAC Name: 3-chloro-4-(chloromethyl)-1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one
InChIKey: OQZCSNDVOWYALR-UHFFFAOYSA-N
SMILES: O=C1N(CC(C1Cl)CCl)C2=CC=CC(C(F)(F)F)=C2
Biological Activity: Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flurochloridone | 99.61% | Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells. | ||||||||||||||||||||
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Flurochloridone (Standard) | ≥98% | Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells. | ||||||||||||||||||||
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- [1]. Zhang F, et al. Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells. Int J Environ Res Public Health. 2022 Apr 11;19(8):4564. [Content Brief]
- [2]. Nikoloff N, et al. Flurochloridone-based herbicides induced genotoxicity effects on Rhinella arenarum tadpoles (Anura: Bufonidae). Ecotoxicol Environ Saf. 2014 Feb;100:275-81. [Content Brief]
