ATF4-IN-1
Based on 1 Customer Validation
ATF4-IN-1 (Compound 21) is an ATF4 inhibitor and also an eIF2B activator. ATF4-IN-1 can be used in research on neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity: 99.29%
- CAS No.: 2991057-76-0
- Formula: C24H21Cl2N3O4
- Molecular Weight:486.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ATF4-IN-1 dose-dependently inhibits the expression of ATF4 in HEK-293T cells, with an IC50 of 32.43 nM[1].
ATF4-IN-1 (0-1000 nM, 3 h) reduces ATF4 protein expression in HEK-293T cells[1].
ATF4-IN-1 (200 nM, 3 h) inhibits the transcription of ATF4 mRNA in HeLa cells[1].
ATF4-IN-1 activates eIF2B, with an EC50 of 5.844 nM in HEK-293T cells[1].
ATF4-IN-1 has an IC50 of 96 μM for inhibiting the proliferation of HEK-293T cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2991057-76-0
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Appearance Solid
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Molecular Weight 486.35
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Formula C24H21Cl2N3O4
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Color White to off-white
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SMILES
O=C(N[C@H]1CC[C@H](C2=NN=C(C3=CC4=CC(Cl)=CC=C4O3)O2)CC1)COC5=CC=C(Cl)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 6.25 mg/mL (12.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0561 mL | 10.2807 mL | 20.5613 mL | 51.4033 mL |
| 5 mM | 0.4112 mL | 2.0561 mL | 4.1123 mL | 10.2807 mL | |
| 10 mM | 0.2056 mL | 1.0281 mL | 2.0561 mL | 5.1403 mL |
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