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  6. YXX0237

YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases.

For research use only. We do not sell to patients.

YXX0237

YXX0237 Chemical Structure

CAS No. : 860445-85-8

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YXX0237 Related Antibodies

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Description

YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases[1].

In Vitro

YXX0237 (10 μM) upregulate FGF21 and GDF15 mRNA in primary liver cells via activation of the ISR/ATF4 transcriptional axis[1].
YXX0237 increases FGF21 and GDF15 mRNA in primary liver cells with EC50s of 11.17 and 1.486 μM[1].
YXX0237 exhibits low cytotoxicity in
HEPG2 and Primary Hepatocytes with CC50s >100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YXX0237 Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUClast Tmax T1/2 Vz/F CL/F MRTlast
Mice[1] 100 mg/kg p.o. 3291.70 ng/mL 23942.32 ng·h/mL 0.50 h 2.27 h 13685.55 mL/kg 4170.41 mL/mg/kg 6.97 h
In Vivo

YXX0237 (50 and 100 mg/kg; p.o.; sigle dose) upregulates FGF21 and GDF15 expression at both mRNA and protein levels in mice[1].
YXX0237 (25, 50 and 100 mg/kg; p.o.; daily for 3 days) exhibits anti-hypoxia effect in mice[1].
YXX0237 (125, 250 and 500 mg/kg; p.o.; single dose) exhibits low in vivo toxicity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 50 and 100 mg/kg
Administration: p.o.; sigle dose
Result: Upregulated FGF21 and GDF15 expression at both mRNA and protein levels in mouse livers.
Animal Model: Mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: p.o.; daily for 3 days
Result: Significantly prolonged the survival time of mice under hypoxic conditions.
Exhibited anti-hypoxia effect in a dose-dependent manner.
Molecular Weight

229.30

Formula

C12H11N3S
CAS No.
SMILES

CC1=CC=CC(C(NC2=NC=CC=C2)=S)=N1
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YXX0237 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YXX0237860445-85-8YXX 0237YXX-0237OthersmiceISR/ATF4 transcriptional axisGDF15acute mountain sicknessFGF21hypoxia-related diseasesInhibitorinhibitorinhibit

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