PERK/eIF2α activator 1
Based on 1 Customer Validation
PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM.
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- Reinheit : 98.88%
- CAS. Nr.: 1178583-17-9
- Formel: C24H29NO7
- Molecular Weight:443.49
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.26 μM
Compound: 3b
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 28117202] |
| HepG2 | IC50 |
2.64 μM
Compound: 3b
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 28117202] |
Chemical Information
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CAS. Nr. 1178583-17-9
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Appearance Solid
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Molecular Weight 443.49
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Formel C24H29NO7
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Color Light yellow to yellow
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCCCCN(CCO)CCO)=CC(O)=C13)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (225.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2548 mL | 11.2742 mL | 22.5484 mL | 56.3711 mL |
| 5 mM | 0.4510 mL | 2.2548 mL | 4.5097 mL | 11.2742 mL | |
| 10 mM | 0.2255 mL | 1.1274 mL | 2.2548 mL | 5.6371 mL | |
| 15 mM | 0.1503 mL | 0.7516 mL | 1.5032 mL | 3.7581 mL | |
| 20 mM | 0.1127 mL | 0.5637 mL | 1.1274 mL | 2.8186 mL | |
| 25 mM | 0.0902 mL | 0.4510 mL | 0.9019 mL | 2.2548 mL | |
| 30 mM | 0.0752 mL | 0.3758 mL | 0.7516 mL | 1.8790 mL | |
| 40 mM | 0.0564 mL | 0.2819 mL | 0.5637 mL | 1.4093 mL | |
| 50 mM | 0.0451 mL | 0.2255 mL | 0.4510 mL | 1.1274 mL | |
| 60 mM | 0.0376 mL | 0.1879 mL | 0.3758 mL | 0.9395 mL | |
| 80 mM | 0.0282 mL | 0.1409 mL | 0.2819 mL | 0.7046 mL | |
| 100 mM | 0.0225 mL | 0.1127 mL | 0.2255 mL | 0.5637 mL |
PERK/eIF2α activator 1 Related Classifications
HY-158196 Related Classifications
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