ISR-IN-1
Based on 1 Customer Validation
ISR-IN-1 is an integrated stress response (ISR) inhibitor targeting eIF2B. ISR-IN-1 enhances eIF2B guanine nucleotide exchange factor activity, stabilizes eIF2B heteropentamer dimers via symmetrical protein-protein interface binding, and releases global protein synthesis inhibition from phosphorylated eIF2αα. ISR-IN-1 can be used for the research of prion disease.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 1628478-15-8
- Formula: C22H22Cl2F2N2O4
- Molecular Weight:487.32
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Aging Compound Library
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MCE Bioactive Compound Library
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Bioactive Compound Library
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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eIF2-β |
ISR-IN-1 (Compound 48) (7 h) potently antagonizes the integrated stress response in HEK293T cells with an EC50 of 0.6 nM, restoring protein synthesis in tunicamycin-stressed cells by activating eIF2B[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1628478-15-8
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Appearance Solid
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Molecular Weight 487.32
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Formula C22H22Cl2F2N2O4
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Color Off-white to light yellow
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SMILES
FC(C=C1OCC(N[C@H](CC2)CC[C@@H]2NC(COC3=CC(F)=C(C=C3)Cl)=O)=O)=C(C=C1)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 8.33 mg/mL (17.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0520 mL | 10.2602 mL | 20.5204 mL | 51.3010 mL |
| 5 mM | 0.4104 mL | 2.0520 mL | 4.1041 mL | 10.2602 mL | |
| 10 mM | 0.2052 mL | 1.0260 mL | 2.0520 mL | 5.1301 mL | |
| 15 mM | 0.1368 mL | 0.6840 mL | 1.3680 mL | 3.4201 mL |
ISR-IN-1 Related Classifications
HY-153074 Related Classifications
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