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ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM).

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ISR-IN-1 Chemical Structure

ISR-IN-1 Chemical Structure

CAS No. : 1628478-15-8

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5 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM)[1].

Molecular Weight

487.32

Formula

C22H22Cl2F2N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(C=C1OCC(N[C@H](CC2)CC[C@@H]2NC(COC3=CC(F)=C(C=C3)Cl)=O)=O)=C(C=C1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0520 mL 10.2602 mL 20.5204 mL
5 mM 0.4104 mL 2.0520 mL 4.1041 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0520 mL 10.2602 mL 20.5204 mL 51.3010 mL
5 mM 0.4104 mL 2.0520 mL 4.1041 mL 10.2602 mL
10 mM 0.2052 mL 1.0260 mL 2.0520 mL 5.1301 mL
15 mM 0.1368 mL 0.6840 mL 1.3680 mL 3.4201 mL
20 mM 0.1026 mL 0.5130 mL 1.0260 mL 2.5650 mL
25 mM 0.0821 mL 0.4104 mL 0.8208 mL 2.0520 mL
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ISR-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISR-IN-11628478-15-8OthersERER StressATF4integrated stress responseInhibitorinhibitorinhibit

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ISR-IN-1
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HY-153074
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